Scientist I, Cryo-EM

Frederick National Laboratory for Cancer Research (FNLCR)

Frederick, MD, United States


The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise. The Center for Molecular Microscopy (CMM) main purpose is to provide access to Electron Microscopy Techniques using state-of-the-art equipment to the intramural cancer research community focusing on collaborating with CCR/NCI Investigators.


In contributing to the CMM mission, the successful candidate will develop and maintain the CMMs data collection pipeline, data quality control measures and data processing. Specifically, the data analysis specialist will perform the following:

  • Perform single particle cryo EM data analysis to obtain 3D volumes using Relion, cryosparc and other related software
  • Perform cryo-tomography data analysis using imod and other related software
  • Develop and assemble workflows for high-throughput transfer and quality control of cryo-EM images
  • Coordinate CMM infrastructure needs with IT support department
  • Maintain and support server storage and work with IT support on any potential issues
  • Develop and maintain more efficient workflows, feedback, and progress reports on projects
  • Provide technical advice to investigators on data analysis and processing 


  • Possession of a Doctorate degree from an accredited college or university according to the Council for Higher Education Accreditation in Biological Sciences, Structural Biology, or related discipline. Foreign degrees must be evaluated for U.S. equivalency
  • No work experience required with a Doctorate degree
  • EM as well as cryo-tomography data processing experience is required
  • Experience preparing detailed, concise reports
  • Good verbal and written communication skills
  • Must be able to obtain and maintain a security clearance


  • Experience with single particle cryo
  • Experience with micro-ED data processing
  • Experience with command line Linux environment and Linux scripting
  • Experience in data management and data analytics
  • Experience in running analytical data reports
  • Experience with electron microscopy
  • Experience with programming in Phyton

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (

Please apply via recruiter’s website.