Scientist - Chemical Biology

Eisai Inc.

Cambridge, MA, United States

Eisai Inc. was established in 1995 and began marketing its first product in the United States in 1997. Since then we have rapidly grown to become a fully integrated pharmaceutical business. Eisai’s areas of commercial focus include neurology, gastrointestinal disorders and oncology/critical care. The company serves as the U.S. pharmaceutical operation of Eisai Co., Ltd., a research-based human health care (hhc) company that discovers, develops and markets products throughout the world. 


Eisai has a global product creation organization that includes U.S.-based R&D facilities in Massachusetts, New Jersey, North Carolina and Pennsylvania as well as manufacturing facilities in Maryland and North Carolina. The company’s areas of R&D focus include neuroscience; oncology; vascular, inflammatory and immunological reaction; and antibody-based programs. 


Eisai recognizes that we are the Company’s greatest asset. To this, Eisai is committed to providing us an enabling and empowering work environment that allows us to grow and thrive. In our diverse organization, we adhere to a strict commitment to our values of Integrity, Respect, Professionalism, Quality and Teamwork. We therefore invite you to explore this job opportunity or any others that may match your qualifications and interests. 


Recognizing the potential for human genetics and precision chemistry to disrupt the drug discovery paradigm, Eisai recently announced establishment of the new Eisai Center for Genetics Guided Dementia Discovery (G2D2). This industry-unique center will occupy a purpose-designed state-of-the-art 50,000 sq. ft. research facility in Cambridge, MA currently scheduled to be completed in spring 2019. The mission of the new center is to accelerate drug discovery and development using human genetics to drive multi-disciplinary team-based progress towards medicines that address unmet patient needs. The predominant research focus of G2D2 will be immunodementia: a new concept for next-generation therapeutics for Alzheimer’s Disease and other dementias that targets immune/inflammation related mechanisms. Our approach is premised upon and continuously incorporates robust insights from human genetics and other sources of human biology. This research focus builds upon Eisai’s considerable experience in and commitment to neurology research, and to our human health care mission which recognizes the profound impact of Alzheimer’s and related dementia on patients and their caregivers. More information about G2D2 is provided here (http://eisai.mediaroom.com/2018-06-12-Eisai-Inc-to-Launch-Center-for-Genetics-Guided-Dementia-Discovery-in-Cambridge-Massachusetts), and about Eisai’s Neurology strategy and pipeline are provided here (https://www.eisai.com/index.html)  


You will join a highly interactive and collaborative team spanning a broad range of drug discovery capabilities including: data sciences (genetics and informatics), wet lab biology (in-vitro and in-vivo), drug discovery platforms (biochemistry, chemical biology, assay development, structural biology, screening, drug safety and DMPK), and chemistry (including application of novel small molecule and anti-sense oligonucleotide approaches). At Eisai, we highly value both internal and external collaboration and pursue flexible research models with a range of external scientific partners to accelerate delivery of innovative medicines. As an Eisai employee you will also spend at least 1% of your working time with patients and families to ensure that the innovation you drive is based on an understanding of their real needs. 


G2D2 builds upon the success of the Eisai AiM Institute (described here: www.EisaiUS-AIM.com). This role will initially be located at the Eisai AiM Institute in Andover, MA, and you will be a key part of our transition to the new center in Cambridge (this transition is scheduled to be completed by spring 2019).  


Job Summary:


The Scientist, Chemical Biology is expected to work independently to perform and analyze chemical biology and proteomic assays in a team environment focusing on early stage drug discovery. The incumbent is expected to work closely with structure biologists, chemists, data scientists, and cell biologists during the design and implementation of the assays. This position requires expertise in chemical biology and proteomics, ideally in the areas of neuroscience and immune-biology.  Strong communication skills are required, and a broader understanding of the drug discovery process is a plus.


Essential Functions:

 

1. Design and develop highly effective biochemical probes for in vitro and in vivo assay development  

2. Establish cell-free and cell-based assays to evaluate macromolecule targeting and modification 

3. Work closely with both biology and chemistry teams to develop quantitative mass spectrometry-based proteomics studies 

4. Analyze, interpret, and deliver results in timely fashion  

5. Communicate effectively with internal and external collaborators to achieve company objectives 

6. Work effectively in multi-disciplinary team environment 

  

Job Qualifications:


* Must have a Ph.D. with post-doctoral research experience in relevant fields including probe design, macromolecule modification, and mass spectrometry-based quantitative proteomics.

* Experience with state-of-the-art mass spectrometry-based proteomics, including experiment design, method development, and data analysis

* Experience with probe design and various detection methods such as fluorescence-based detection

* Good understanding and experience in cell biology

* Proactively evaluate and implement new technologies to advance our drug discovery projects

*The ability to work in our Andover, MA office until the move to Cambridge, MA occurs, anticipated to be Spring of 2019

JOB REQUIREMENTS

* Must have a Ph.D. with post-doctoral research experience in relevant 

fields including probe design, macromolecule modification, and mass 

spectrometry-based quantitative proteomics.

* Experience with 

state-of-the-art mass spectrometry-based proteomics, including experiment 

design, method development, and data analysis

* Experience with probe design 

and various detection methods such as fluorescence-based detection

* Good 

understanding and experience in cell biology

* Proactively evaluate and 

implement new technologies to advance our drug discovery projects

*The 

ability to work in our Andover, MA office until the move to Cambridge, MA 

occurs, anticipated to be Spring of 2019

*Department Name 

Discovery Sciences



Here at Eisai, we are rewarded with highly competitive salaries, incentive awards, a comprehensive benefits package (Medical, Dental, Prescription and Vision Plans) 401k, Flexible Spending Accounts, Life and Disability Insurance, and other great programs. 


Eisai is committed to a policy of equal employment opportunity for all employees and applicants. The Company also strives for a work environment free from discrimination and harassment. It is Eisai’s policy to comply with all applicable federal, state and local laws and regulations regarding nondiscrimination in employment and not to discriminate against any employee or applicant for employment on the basis of any protected status, including, but not limited to, race, color, national origin, religion, sex, age, disability, pregnancy, ancestry, creed, alienage or citizenship status, sexual orientation, gender identity and expression, marital status, military/veteran status, genetic information, or any other protected characteristic as established by law. 


Eisai is an Equal Opportunity Employer &ndash; Minority / Female / Disability / Vet from tblHiringOrgDefaults<img height=1 width=1 border=0 src=https://eisai.contacthr.com/70800997.jpg />


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