Leiden University Medical Center (LUMC)

Researcher (Postdoc) Unravelling the agonistic potential of MuSK Monoclonal Antibodies

Leiden University Medical Center (LUMC)

Leiden, Netherlands

In short
job vacancy number : D.19.MH.RD.03
closing date for application : December 1st 2019

The position
Are you intrigued to study how patient-derived monoclonal antibodies function, and might have therapeutic potential? And would you like to be part of a young and dynamic team? Then read on.

You will be involved in ongoing research projects in the research group of Dr. Maartje Huijbers. The research group studies the pathophysiology of neuromuscular autoimmune diseases like myasthenia gravis (MG). In addition, there is a special interest in autoimmune diseases predominantly mediated by IgG4 autoantibodies. For one of these disorders, MuSK MG, monoclonal antibodies of patients have been isolated which facilitates the study of the pathophysiology of this disease. In addition, these antibodies have special features that might enable therapeutic applications. Your project will include the isolation of new monoclonal antibodies from patients’ immune cells and the analysis of the genetic, functional and immunological characteristics of these antibodies. You will identify the antibodies with the most favourable features in vitro and test their effects in in vivo models. The application of these antibodies in our animal models will be one of the most important aspects of this project. You will collaborate closely with a technician, who is also working on this project. These studies are facilitated by a variety of genomic and proteomic, antibody-oriented technologies, as well as a variety of cellular and animal models that the lab has at its disposal.

The profile
You are an enthusiastic, driven researcher who:

  • enjoys working on fundamental and mechanistic research questions
  • has common experience with common molecular biology tools and animal experimentation
  • preferably has experience with FACS and RNA sequencing analysis
  • is accurate and can work independently within a team
  • possess solid communication skills in English.

The offer
You will be employed on the basis of a 36-hour week. Appointment is for a minimum of one year. The salary will depend on your qualifications and experience, with a maximum of € 4,481 gross per month based on a full time position (scale 10 of the Collective Labor Agreement for University Hospitals).

Working at LUMC
The LUMC is a center for medical innovation that aims to improve patient care through leading international research. So as to also provide our patients with a safe and friendly environment, we need doctors, medical care specialists, support staff and academic researchers.

You will work in between two departments at the LUMC: Human Genetics (Prof. Dr. Silvère van der Maarel, head of the department) and Neurology (Prof. Dr. Jan Verschuuren, head of the department). Both departments have a longstanding collaboration on research of Neurological Motor Disorders. This research is embedded in the LUMC Medical Research Profile ‘Translational Neurosciences’. The collaboration facilitates translational research based on fundamental research, patient material and clinical expertise. It is also supported through interactions with other departments both within and outside the LUMC. The Neuroimmunology research team is led by Dr. Maartje Huijbers.

More information
A detailed description of this position can be found on www.werkenbijhetlumc.nl (select ’Working at the LUMC’). If you have any questions or would like more information about this position, please contact Dr. Maartje Huijbers, senior researcher, Department of Human Genetics/Neurology, telephone: +31(0)71 526 94 84, e-mail: m.g.m.huijbers@lumc.nl.

References can be requested as part of the procedure. You might be asked to give a presentation.

How to apply
If you are interested in this position, please complete the application form by December 1st, 2019 at the latest. You can also apply through the website www.werkenbijhetlumc.nl.

Please apply via recruiter’s website.