Howard Hughes Medical Institute (HHMI) is an independent, ever-evolving philanthropy that supports basic biomedical scientists and educators with the potential for transformative impact. We make long-term investments in people, not just projects, because we believe in the power of individuals to make breakthroughs over time. HHMI scientists have radically advanced the understanding of cells, the brain, the immune system, the development of organs, and how to treat many diseases. Founded in 1953 by aviator and industrialist Howard R. Hughes, HHMI is headquartered in Chevy Chase, Maryland, and employs more than 2,500 people across the U.S.
The Reddien lab at the Whitehead Institute and MIT studies the ability of animals to regenerate missing body parts. This ability has been studied for centuries, yet satisfying explanations for how it occurs have been elusive. How do some animals regenerate and why can’t we? We seek to address this question by studying the cellular and molecular basis for regeneration in highly regenerative organisms. Much of our work utilizes planarians, a classic regeneration model. We seek general regeneration principles by studying additional regenerative organisms and by developing novel model systems. To learn more about the lab, visit their website: http://reddienlab.wi.mit.edu and to learn more about Dr. Reddien, visit: https://biology.mit.edu/profile/peter-reddien/
We are currently seeking an innovative Research Specialist with a strong experimentalist background to work on unique and collaborative projects. The individual will work with Dr. Reddien and other scientists in designing and implementing research projects seeking to address key questions about regeneration. The candidate will also facilitate development of new project areas in the lab. The best candidates will have a strong background in molecular biology, an innate desire for continuous learning and curiosity-driven exploration, enjoy working with others, and have a commitment to rigorous, critical thinking.
- Studies gene function with RNAi and phenotypic analyses in planarians and other organisms
- Uses a variety of antibody labeling, in situ hybridization, and other cell labeling methodologies to study the key cell populations involved in regeneration
- Works on developing novel methods for labeling cells and perturbing gene function using modern molecular methods
- Generates RNA sequencing libraries for study of steps of regeneration and regeneration phenotypes
- Helps in development of novel regeneration model organisms
- Plays a vital collaborative role in the Reddien lab and actively contributes to the research efforts of other lab members
- Develops mastery with molecular, histological, and potentially computational methods that can facilitate training of future new lab members
Required Education and Experience
- PhD. (currently or by May 2020) with experience in molecular biology
- Exceptional oral communication and interpersonal skills
- Expertise in developmental biology and/or computational methods a plus, but not essential
- Experience working with model organisms a plus, but not essential
- Excellent troubleshooting and organizational abilities