Howard Hughes Medical Institute (HHMI)

Research Specialist - CryoEM

Howard Hughes Medical Institute (HHMI)

Dallas, United States

HHMI is seeking a Cryo-Electron Microscopist to support the Structural Biology Laboratory at

UT Southwestern Medical Center in Dallas, Texas.


About the UT Southwestern Structural Biology Laboratory

The Structural Biology Laboratory (Diana Tomchick, Director) is a platform that allows researchers with different expertise to come together in a collaborative setting and tackle biological problems in a comprehensive way. Our publications are representative of the success of this strategy:


UT Southwestern has recently established a new state-of-the-art cryo-electron microscopy facility housing a 200kV Talos Arctica for cryo-EM single particle screening and a 300kV Titan Krios for high-resolution structure determination. A sample grid lab is fully equipped with two Vitrobot robots, a Safematic HV Compact Coating Unit and assorted instruments for sample preparation. This position will support the research of Drs. Youxing Jiang, Lora Hooper, David Mangelsdorf, Kim Orth, Bruce Beutler, Michael Brown, Joseph Goldstein, and many others.


We are seeking a motivated individual to join a team of scientists in the Structural Biology Laboratory at UT Southwestern and participate in the research projects that utilize single particle cryo-electron microscopy technology for protein structure determination.   This position will be filled at the Research Specialist level with a salary commensurate with qualifications and experience.   The Research Specialist will be employed by the Howard Hughes Medical Institute (HHMI), which collaborates with UT Southwestern in conducting advanced biomedical research.


Primary Responsibilities:

  • Work with other team members on sample grid preparation and grid screening
  • Ensure high quality data acquisition on Talos Arctica and Titan Krios
  • Provide guidance in the use of current image processing programs and in structure determination and validation
  • Assist with final manuscript preparation


Required Education and Qualifications:

  • PhD. degree in biochemistry, biology, chemistry, physics or a related field
  • 1-2 years of postdoctoral research experience
  • Expertise in the use of current cryo-electron microscopy methods.
  • Good technical, communication, and teaching skills


Other Useful Skills:

  • Prior experience supporting research in the structural biology field is highly desirable
  • Understanding of how to determine protein structures through cryo-electron microscopy strongly preferred


To Apply: please submit an application via the ‘Apply’ button on this page.


HHMI is an Equal Opportunity Employer. 



For specific inquiries, please contact:


Diana Tomchick, PhD

Director, Structural Biology Laboratory

Department of Biophysics

UT Southwestern Medical Center



Youxing Jiang, PhD

Professor of Physiology and Howard Hughes Medical Institute Investigator

Department of Physiology

UT Southwestern Medical Center



Please apply via recruiter’s website.

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