Research / Senior Scientist – Certara UK, Simcyp Division
Closing Date for Applications: Midnight (UK time), 26th May 2019
Line of Management: Head of Mechanistic Modelling
Position Type: Full Time
Holiday Entitlement: 25 days, plus statutory bank holidays
Salary: £34,000 – £45,000 per annum dependent on qualifications and experience (plus discretionary bonus, pension contribution, health scheme etc.)
Location: Sheffield, UK
We have an immediate opening for a highly motivated research / senior scientist with good working knowledge of developing multi-dimensional mathematical modelling of physiological and biological systems and parameter estimation algorithms established upon robust statistical framework for high order models. The successful candidate will assist with the development of models and algorithms for defining systems pharmacology/biology models concerning safety and efficacy of small and large molecules within Simcyp Simulators. Candidates should have experience of applied mathematics, biostatistics and data analysis. Ideally, this should be in pharmacokinetics-, toxicokinetics- and/or pharmacodynamics- related areas. In particular, candidates should have hand-on experience in development of optimisation algorithms and capable of dealing with complex numerical problems including non-linear mixed effect models. The successful candidate is expected to keep abreast of the latest scientific developments and actively engage with peers and clients within industry, academia and regulatory agencies.
The successful candidate will join an internationally recognised, multidisciplinary research team, providing opportunities for further development of knowledge and skills. The candidate will undertake novel research projects to further expand the capabilities of the Simcyp Simulators, which require a high level of attention to detail, good oral and written communication skills, and the ability to liaise effectively with the software developers. Further, the candidate is expected to provide on-going customer support and education related to the use of the Simulators and to act as tutor on the Company’s well-known educational workshops. The post does not include routine laboratory or clinical work.
We offer a unique and exciting mix of academic and commercial environments which encourage regular attendance at scientific meetings as part of our continuous education programmes.
PhD in pharmaceutical sciences, computational biology, applied mathematics, bioengineering, control or chemical engineering or related fields with at least two years of practical experience.
In-depth understanding and hands-on experience in modelling and simulation principles, statistical data analysis and optimisation algorithms
Good working knowledge of common or specialised modelling and simulation platforms, such as Matlab, R, Phoenix, Simcyp, etc
Proven track record of publications in high impact factor journals
Excellent record of communication skills, as evident by presentation at scientific meetings, and good interpersonal and organizational skills
Working knowledge of Bayesian inference and related numerical techniques
Knowledge of in vitro in vivo extrapolation (IVIVE) techniques
Awareness of R&D process in pharmaceutical companies
Awareness of good software engineering practices
Simcyp is part of Certara, a company which combines sophisticated research and development informatics with the power of predictive science methodologies to span the drug development spectrum and offer pharma a previously unavailable ‘end-to-end’ solution in the quest for improving human health. The Simcyp team conducts cutting-edge research and provides consultancy, knowledge integration tools, algorithms, modelling solutions and databases (implemented in its globally-recognised Simcyp Population-based Simulator) for a client base of major blue-chip pharmaceutical and biotechnology organisations.
Simcyp focuses, in particular, on gathering information required for the modelling and simulation (M&S) of the individual time-course and fate of drugs. We are on course to become the global industry standard, consequently, there is a continuous requirement for high quality people to join us, help in our expansion and share in our success.
Applications: Please apply via our workforcenow.adp.com