The laboratory focuses on the separate as well as combined therapeutic effects of CD4 and CD8 T cells recognizing mutation-encoded cancer-specific antigens on murine or human cancers. The Schreiber laboratory has contributed to a number of important discoveries in the field of cancer immunotherapy, including the identification of the genetic nature of unique tumor-specific antigens and that non-synonymous single nucleotide substitutions causing single amino acid replacements are the basis of the unique individually specific immunogenicity of cancers. The Schreiber lab uses mouse models to study T cell-mediated immunotherapy of progressively growing tumors and how tumor-stroma modifies the therapeutic outcome. The lab uses a combination of sophisticated in vivo and in vitro methodologies (including imaging) ranging from the molecular, cell culture, and tissue to the whole-body level.
The job facilitates and promotes a research project or contributes to the scientific direction of a research resource. Receives a moderate level of guidance and direction. Research Professional will study/develop adoptive T cell therapies in mouse models and humans using syngeneic/autologous mutation specific TCRs engineered to be expressed in peripheral blood T cells. The incumbent will work in close collaboration with our team of leading scientists at the University of Chicago and abroad.Responsibilities
- Directs a comprehensive program leading to the development of autologous T cell-receptor (TCR) therapy targeting cancer-specific mutations in mice as well as in patients.
- Not only conducts experiments and assays but also trains and guides members of the laboratory. Collaborates with a bioinformatics group to identify the trunk mutations that are well expressed.
- Selects appropriate tumor-specific targets for therapy.
- Renewal and updating of existent and/or completion of new animal research, biosafety and radiation as well as clinical research protocols.
- Making, ordering, training and receiving of culture media and reagents.
- Preparation of sterile supplies including glassware. Training and supervision of others to take over these tasks.
- Writes up (detailed design) and executes experiments discussed with the principle investigator (PI). Training and supervision of others to take over these tasks.
- Maintaining a liquid nitrogen cell bank. Training and supervision of others to take over these tasks.
- Guides, motivates and encourages incoming graduate and undergraduate students, postdoctoral fellows, residents and visiting researchers, and to interact productively with other faculty inside and outside the University.
- Serves as a resource for collecting data and performing analysis. Contributes to facilitating and promoting a research project by providing scientific or intellectual information.
- Reviews laboratory protocols and training on new techniques. Manage complex data sets for research.
- Leads the contributions to scientific writing and publications, including protocols and grants.
- Trains new laboratory personnel.
- Performs other related work as needed.
- A doctoral degree in molecular biology, genetics, or immunology.
- Experience in 10xGenomics preparation and downstream analyses, NSG analyses, TIL, B and T cell cultures and separation techniques, vector construction and methods for TCR transfer by viral transduction, electroporation and CRISPR-CAS.
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We seek a diverse pool of applicants who wish to join an academic community that places the highest value on rigorous inquiry and encourages a diversity of perspectives, experiences, groups of individuals, and ideas to inform and stimulate intellectual challenge, engagement, and exchange.