University College London (UCL)

Research Fellow

University College London (UCL)

London, United Kingdom

Great Ormond Street Institute of Child Health

London

Research Fellow

Full Time

The appointment will be on UCL Grade 7. The salary range will be £35,965 – £36,945 per annum, inclusive of London Allowance.

This post is based in the Molecular and Cellular Immunology unit within the Infection, Immunity and Inflammation Programme (III) at the UCL Great Ormond Street Institute of Child Health (ICH). The labs are located in the new Zayed Centre for Research into Rare Disease in Children. Our research is focused on developing effective and safe genome editing and gene therapy strategies for the treatment of immunodeficiencies and investigating the molecular mechanisms underlying hematopoietic diseases. Over the last 15 years the gene therapy programme at UCL ICH and GOSH has grown to become one of the largest programmes worldwide. We have run 7 trials of gene therapy for primary immunodeficiencies, with significant success and with minimal adverse events. The experience and expertise generated has led to the development of other gene and cell therapies for metabolic disease, inherited skin conditions, HIV and T cell therapies for cancer. The programme has attracted international recognition and acclaim for UCL and Great Ormond Street Hospital and is also now attracting significant pharma/commercial interest. There is broad spectrum of expertise ranging from basic vector biology, through proof of concept studies to implementation of clinical trials. Our close relationship with the unique patient population at GOSH allows early translation to clinical studies.

The post holder will undertake translational research and development of new therapies in areas relevant to the laboratory projects, design, develop, and undertake gene-editing procedures using reagents including CRISPR/Cas, TALENs and other nucleases, to isolate, culture and differentiate human hematopoietic stem and progenitor cells, arrange and/or undertake human/murine chimeric modelling to assess stem cell function and perform functional studies by using different techniques including immunostaining, western blotting, flow cytometry, proliferation assays, etc.

These two position are available for 24 months in the first instance.

Applicants must have PhD degree in a relevant subject. The successful applicant will have experience in culture and manipulation of cell lines, laboratory work in molecular biology and prior knowledge and experience in techniques of flow cytometry, western blotting, PCR, cloning. Experience in culture and/or manipulation of human stem cells is desirable.

For further details about the vacancy and how to apply online please go to https://www.ucl.ac.uk/human-resources/working-ucl/jobs-ucl and search on Reference Number 1856799.

If you have any queries regarding the application process, please contact Madhur Sharma on ich.hr@ucl.ac.uk quoting job reference 1856799.

Closing Date: 8 Feb 2020.

Latest time for the submission of applications: 23.59.

Interview Date: TBC.

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