University College London (UCL)

Research Fellow/ Senior Research Fellow in Bioinformatics/Computational Biology

University College London (UCL)

London, United Kingdom

UCL Research Department of Structural and Molecular Biology
Research Fellow/ Senior Research Fellow in Bioinformatics/Computational Biology
Full Time
The appointment will be on UCL Grade 7. The salary range will be £35,965 – £43,470 Grade 7 & £44,674 – £52,701 Grade 8, inclusive of London Allowance.
Exploiting evolutionary data to identify protein functional families for modelling protein structures and predicting their functions and functional sites.
CATH is an internationally renowned resource providing information on sequence-structure-function relationships for over a hundred million proteins. We are recruiting a postdoctoral researcher at either Grade 7 or 8, depending on experience. This post will develop new computational algorithms and protocols exploiting machine learning for better functional classification of domains in CATH. This is a collaborative project with PDBe, UniProt, SWISS-MODEL, Rosetta, ModBase which will improve the functional classification of CATH domains to provide templates for improved protein structure prediction and to improve functional site prediction. The Orengo group exploits CATH data in a range of collaborations with experimental groups researching the impacts of genetic variations (eg cancer studies, protein design to engineer enzymes for improved plastic degradation) and the postdoc would also be able to contribute to these projects. Expertise in website design and development would also be an advantage to present the functional classification data intuitively to the large community exploiting this CATH data.
This post is funded for 3 years in the first instance and will be based in the lab of Professor Christine Orengo at UCL. The project is in collaboration with the Protein Databank at EBI.
To apply at Grade 7 and above, you should hold a PhD in a relevant field (computer science, bioinformatics or computational biology) or be about to submit a thesis. Advanced programming skills and experience of Perl or Python, databases and SQL, Linux or other unix-like operating systems are all essential for the role. Previous experience in bioinformatics research is desirable, especially in protein structure-function analysis and prediction.
If the PhD is yet to be awarded, initial appointment will be at research assistant Grade 6B (salary £31,479-£33,194 per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis.
In addition to the above, to be appointed at Grade 8 as Senior Research Fellow the successful candidate will have an independent research reputation, with evidence of national recognition of achievement within the appropriate subject area. Evidence of completed research, which has been published, as well as a suitable publication record, and evidence of knowledge transfer/exchange activities is also essential.
For further details about the vacancy and how to apply online please go to and search on Reference Number 1822760

For informal queries on the role, please contact Prof Christine Orengo For queries regarding the application process, please contact the Biosciences Staffing team
Closing Date: 20 October 2019
Latest time for the submission of applications: 23:59.
Interview Date: tbc
We particularly welcome female applicants and those from an ethnic minority, as they are under-represented within UCL at this level.
UCL Taking Action for Equality
We will consider applications to work on a part-time, flexible and job share basis wherever possible.
Our department holds an Athena SWAN Bronze award, in recognition of our commitment to advancing gender equality.
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