Nanyang Technological University (NTU) is one of the leading research-intensive institutions in Singapore that offers a collaborative and multi-disciplinary environment for innovative research and scientific training and is ranked 13th globally. We are seeking talented and highly motivated postdoctoral or master’s postgraduate researchers to join the Transcription and Chromatin Regulation Laboratory (http://sbs.ntu.edu.sg/Faculty/Li_Yinghui/Pages/Li%20Yinghui.aspx) for both Computational Biology and Epigenomics studies.
The Transcription and Chromatin Regulation Laboratory (http://sbs.ntu.edu.sg/Faculty/Li_Yinghui/Pages/Li%20Yinghui.aspx) at School of Biological Sciences (NTU) is a vibrant team of molecular cell biology researchers and computational biologists focused on elucidating the enhancer reprogramming and chromatin dynamics during cancer development. The overall goal of our funded projects is to uncover the impact of oncogenic/inflammatory mediators and non-coding RNAs on enhancer regulation, leading to the activation of cancer driver genes. (Nature Cell Biology 2015, 17: 1327-38; PNAS 2016, 113: 14402-07; Nature Communications 2018, 9: 3183). We are seeking motivated and innovative postdoctoral fellows or research associates in the disciplines of computational biology, data analytics and/or epigenomics who are interested in developing computational approaches or molecular and cell biology/biochemistry methods to study the changes of genomic and epigenomic profiles (e.g. enhancer-gene interactions) during cancer progression.
The Computational Biology studies involve the identification of cancer-specific enhancer signatures and their association with gene regulation. The successful candidate should be experienced in working with a variety of next-generation-sequencing (NGS) data including RNA-seq, ChIP-seq, ATAC-seq and Hi-ChIP and possess a keen interest in developing bioinformatics pipelines for multi-omics data integration. Strong programming skills in R and/or Python and prior experience with NGS analysis in at least 1-2 of the above genomics datasets are essential. Expertise in developing algorithms for multi-omics data integration, machine learning prediction tools or analysis of large patient datasets will be highly advantageous.
The Epigenomics studies involve deciphering the mechanisms of enhancer-gene interactions, epigenetic changes (e.g. RNA modifications) and non-coding RNA functions in transcriptional regulation during cancer progression. The successful candidate should possess extensive knowledge and experience in RNA biology, epigenetics or chromatin regulation. Competence in CRISPR epigenome editing, nuclear run-on assays, in vitro transcription and RNA pull-down, lncRNA characterization or genomics work such as ChIP-seq and chromosome conformation capture (3C) methods will be preferred.
• Ph.D. or M.Sc. in the relevant disciplines of computational biology, bioinformatics, computer science, molecular & cell biology, genomics or RNA biology;
• Track record of peer-reviewed publications in relevant disciplines will be advantageous;
• Ability to write research articles and keep well-organized scientific documentation;
• Excellent interpersonal, written and oral communication skills;
• A strong team focus and ability to work independently;
• A demonstrated ability to supervise PhD students and junior research staff is a plus.
We offer a stimulating and dynamic research environment that is supported by well-equipped infrastructure and resources. Researchers have opportunities for scientific development and collaborations with other research institutions. A competitive remuneration package (with health insurance and other benefits) that is commensurate with the qualifications and relevant experience of the successful candidate will be provided.
Interested applicants are invited to apply directly at our NTU Career Portal:
Please upload your complete resumé (include list of publications and at least two academic referees) and research statement. We regret that only shortlisted candidates will be notified.