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A postdoctoral position is available immediately in the Department of Neurology with Dr. Eugenia Trushina in Rochester, Minnesota. This one-year renewable position will be focused on preclinical studies of therapeutic efficacy and molecular mechanisms of small molecule mitochondria complex I inhibitors developed in the laboratory to treat Alzheimer’s Diseases. The laboratory integrates several disciplines, including mitochondria biology, biochemistry, systems biology approaches (metabolomic, transcriptomic, proteomic), and has a strong translational focus, with activities in preclinical studies and development of novel therapeutics and biomarkers of efficacy. We are seeking a highly motivated individual with a solid background in mitochondria field. The successful candidate will be a self-driven scientist, enjoying challenging research projects in a supportive multidisciplinary environment, and working in a timely fashion with team members. Investigation will be conducted in human iPSC-derived brain cells (neurons, astrocytes, microglia) and neuronal cell lines. Some experiments will require working with mouse tissues and biofluids. The in-depth knowledge of major biochemistry techniques relevant to the analysis of mitochondrial dynamics and function, cellular metabolism and energetics, and the experience with omics data analysis and interpretation are mandatory.
- Candidates must have a Ph.D. or M.D./Ph.D. degree in Biological Sciences and have at least two-year research experiences in the field of neuroscience with the emphasis on mitochondria.
- Proficiency in techniques involving mitochondrial dynamics, function, morphological and energetic assessment (e.g., a Seahorse Extracellular Analyzer, Oroboros, confocal microscopy, electron microscopy, etc.) and basic cell biology techniques including ELISA, SDS-PAGE, western blot, PCR, etc.
- Proficiency in in vitro work with primary, continuous, and iPSC-derived cell cultures.
- The work will include single-cell analysis, isotope labeling, and other advanced techniques to establish cell-specific response to treatment.
The candidate will also be expected to write manuscripts reporting research findings, originate new, related, or follow-up research projects, and to originate/participate in grant proposal writing to support the lab. This opportunity is open to U.S. and non-U.S. residents; position is available immediately.
Applications, including curriculum vitae and bibliography, summary of past accomplishments, and three letters of recommendation, should be submitted together.
A Research Fellow at Mayo Clinic is a temporary position intended to provide training and education in research. Individuals will train in the research program of a Mayo Clinic principal investigator. Qualified individuals will demonstrate the potential for research as evidenced by their training and peer-reviewed publications and should become competitive for national research grants. Proof of English proficiency is required for J-1 Short-Term Scholars, Research Scholars, Professors, Specialists, and Student Interns sponsored by Mayo Clinic.
The following is required for completeness of application:
* Current curriculum vitae with bibliography
* Proof of doctoral degree (copy of diploma or final transcript with English translation, if applicable) or a letter from your university’s Registrar office indicating you have fulfilled all doctoral program requirements and are eligible to graduate.
Must have a Ph.D., M.D., or equivalent doctoral degree in a field deemed relevant by the program. Research Fellow is appropriate for individuals who have completed no more than one prior postdoctoral fellowship, at Mayo Clinic or elsewhere.
Mayo Clinic is located in the heart of downtown Rochester, Minnesota, a vibrant, friendly city that provides a highly livable environment for more than 34,000 Mayo staff and students. The city is consistently ranked among the best places to live in the United States because of its affordable cost of living, healthy lifestyle, excellent school systems and exceptionally high quality of life.