University College London (UCL)

Research Fellow, Neurodegenerative Disease

University College London (UCL)

London, United Kingdom

Alzheimer’s Research UK – Drug Discovery Institute

Research Fellow, Neurodegenerative Disease

The Alzheimer’s Research UK Drug Discovery Institute (ARUK UCL DDI), located at University College London (UCL), has the goal of finding new therapies for neurodegenerative disease. As part of the UCL Queen Square Institute of Neurology it is integrated into the world-renowned UCL Neuroscience community and closely aligned with the Dementia Research Institute at UCL. Academic scientists supporting the activities of the ARUK UCL DDI are Institute of Neurology Professors Giampietro Schiavo and John Hardy.

A Research Fellow position is available as part of this novel and exciting initiative. The post holder will be jointly located in the laboratory of Dr Afia Ali, School of Pharmacy at UCL. You will use acute brain slice electrophysiology to explore the role of P2Y1 purinergic receptors in modulating neuronal hyperexcitability in models of Alzheimer’s disease. Additionally, you will use pharmacological tools, and potentially genetic approaches, to explore other mechanisms that modulate astrocyte function, and the mechanisms by which astrocytes influence neuronal activity; these “target validation” studies will inform new drug discovery targets in the ARUK UCL DDI. There will also be the opportunity to utilise imaging approaches to map the expression of key targets in the brain.

Applicants must have a PhD in a neurobiology related topic. The successful candidate will have experience in electrophysiology, good inter-personal skills with an ability to work co-operatively in a multidisciplinary setting, an excellent academic record with evidence of creative work, and the ability to maintain high standards of technical excellence and experimental reproducibility. A depth of experience in a variety of molecular and cellular biology techniques, and cellular imaging and experience in preparation of and recording from acute brain slices are desirable.

The post is available immediately and funded by a grant from ARUK for the period to 31 August 2022 in the first instance. Salary will be in the range £35,328 – £42,701 per annum including London Allowance on the UCL Grade 7 scale, superannuable. Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at research assistant Grade 6B (salary £30,922 – £32,607 per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis. If the PhD has not yet been granted, the final accepted version of the thesis must have been submitted to the degree-granting university by the start date.

You should apply for this post through UCL’s online recruitment – where you can download a job description and person specification using ref: 1824488.

For further information please contact Miss E Bertram, HR Manager, UCL Queen Square Institute of Neurology, 23 Queen Square, London, WC1N 3BG (email: More information on the post or Alzheimer’s Research UK UCL Drug Discovery Institute is available from Prof Paul Whiting (email:

Closing date: xx September 2019

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