University of Leeds

Research Fellow in Single-Enzyme Biophysics

University of Leeds

Leeds, United Kingdom

Research Fellow in Single-Enzyme Biophysics,
Faculty of Biological Sciences

Ref: FBSBM1138
Grade 7 (£33,797 – £40,322 p.a.)
Fixed-term for 11 months

Due to funding limitations it is unlikely an appointment will be made above £33,797.

Are you an ambitious researcher looking for your next challenge? Do you have an established background in membrane proteins or single enzyme biophysics? Do you want to further your career in one of the UKs leading research intensive Universities?
You are invited to join an interdisciplinary BBSRC-funded project to work on a project aiming to study the proton-pumping mechanism of mitochondrial complex I. Complex I (NADH-ubiquinone oxidoreductase) plays a crucial role in cellular bioenergetics. Complex I is a known source of radical oxygen species (ROS) and its malfunctions have important consequences for (human) health and aging. Structural information from both crystallography and electron cryo-microscopy (cryo-EM) has been used to formulate several models on the proton-pumping mechanism of complex I, but none of them have been experimentally verified. We have recently developed a single-enzyme methodology for proton pumping enzymes and in this project you will use this methodology to study the proton-pumping mechanism of complex I.

This BBSRC-funded project is a collaboration between the University of Leeds and the MRC Mitochondrial Biology Unit in Cambridge. You will be based in a multidisciplinary biophysics research team supervised by Prof. Lars Jeuken and will work in collaboration with Prof. Judy Hirst and her team in Cambridge.

You should have, or be, close to completing a PhD in a relevant subject area (e.g. chemistry, biochemistry, physics). With a background in bioinorganic chemistry, single-enzyme biophysics or membrane proteins you should be able to work effectively both independently and within a multidisciplinary team.

The University of Leeds and the Faculty of Biological Sciences are committed to providing equal opportunities for all and offer a range of family friendly policies. The University is a charter member of Athena SWAN (the national body that promotes gender equality in higher education), and the Faculty of Biological Sciences was reawarded a Bronze award in 2017. We are proud to be an inclusive Faculty that values all staff, and are happy to consider job share applications and requests for flexible working arrangements from our employees. Our Athena SWAN webpage provides more information.

What does the role entail?
As a Research Fellow your main duties will include:
• Designing, planning and conducting a programme of investigation, in consultation with Prof. Lars Jeuken;
• Generating independent and original research ideas and methods in the fields of bioenergetics and single-enzyme biophysics with an aim to extend the research portfolios of the Jeuken group at the University of Leeds and the MRC Mitochondrial Biology Unit in Cambridge;
• Making a significant contribution to the dissemination of research results by publication in leading peer-reviewed journals, and by presentation at national and international meetings;
• Working independently and as part of a larger team of researchers, both internally and externally to develop new research links and collaborations and engage in knowledge transfer activities where appropriate;
• Contributing to the supervision of junior researchers and PhD students and acting as a mentor to less experienced colleagues;
• Evaluating methods and techniques used and results obtained by other researchers and relating such evaluations to your own research;
• To contribute to, and to encourage, a safe working environment.
These duties provide a framework for the role and should not be regarded as a definitive list. Other reasonable duties may be required consistent with the grade of the post.

What will you bring to the role?
As a Research Fellow you will have:
• A PhD (or be close to completion) in Chemistry, Biochemistry, Biophysics or a closely allied discipline;
• Experience in single-enzyme biophysics, membrane proteins or bioinorganic chemistry;
• Strong analytical skills, with the ability to work accurately and carefully, designing, executing and writing up research independently;
• A developing track record of peer reviewed publications in international journals;
• Excellent communication skills, both written and verbal and the ability to communicate your research at national and international conferences;
• The ability to work well both independently and as part of a team;
• Strong initiative and a pro-active approach, with excellent organisational, planning and self-management skills, including the ability to prioritise workloads to meet deadlines/demand and deliver high quality under pressure;
• A strong commitment to your own continuous professional development.

You may also have:
• Experience in bioelectrochemisty or MatLab or similar data analytical software;
• Evidence of pursuing external funding to support research.

To explore the post further or for any queries you may have, please contact: Professor Lars Jeuken, Professor of Molecular Biophysics, Tel: +44 (0)113 343 3829, Email:

To apply please visit
Closing Date: 8th March 2020

Please apply via recruiter’s website.