Research Fellow in Leukaemia Stem Cell Biology & Single Cell Genomics

University College London (UCL)

London, United Kingdom

Great Ormond Street Institute of Child Health

London

Research Fellow in Leukaemia Stem Cell Biology & Single Cell Genomics

Full Time

The appointment will be on UCL Grade 7. The salary range will be £35,965 – £38,993 per annum, inclusive of London Allowance.

We are seeking an enthusiastic and highly motivated post-doctoral researcher to join the research group of Dr Alice Giustacchini at the Great Ormond Street Institute of Child Health at UCL, within the Section of Molecular and Cellular Immunology.

Molecular and cytotoxic therapies in cancer can often induce remission without achieving a complete disease eradication, potentially resulting in relapse and poor prognosis. A better understanding of cell-to-cell heterogeneity in cancer is crucial for the development of effective therapeutic strategies accounting for the complexity of the disease. We have previously shown that Myeloid Leukaemia stem cells display a high degree of heterogeneity, with cells carrying a distinct transcriptomic signature of “therapy-resistance” being identified already at diagnosis and progressively enriched with treatment1. With this project, combining state of the art single-cell genomics and proteomic measurements with stem cell functional assays, we aim at the identification and characterization of leukaemia stem cells responsible for treatment escape and disease relapse.

The post holder will have the opportunity to interact with a lively community of researchers involved in single-cell genomics studies at ICH and will closely interact with the team of Dr Sergi Castellano, Head of the Genome Biology and Precision Medicine section. Moreover, at ICH, we are ideally placed at the intersection of basic research and clinical translation. The selected post-doc will have the unique opportunity to closely interact with the group of Prof Persis Amrolia, Head of the Section of Molecular and Cellular Immunology and leader in the field of CAR T-cell therapy of haematological malignancies.

The project is funded by Cancer Research UK (CRUK) for 2 years or until 30/04/2022 in the first instance.

We are seeking a creative researcher with prime interest in stem cell biology, cancer and single cell genomics. Candidates should have a PhD in Molecular/Cellular Biology or equivalent. Extensive experience in multi-colour FACS, haematopoietic stem cell assays, molecular biology (qRT-PCR, RNA-seq) are essential. Experience in single cell biology (mass cytometry and transcriptomic) are highly desirable. Experience in computational analyses of single cell genomic datasets would be an asset.

For further details about the vacancy and how to apply online please go to http://www.ucl.ac.uk/hr/jobs/ and search on Reference Number 1860908.
If you have any queries regarding the application process, please contact Madhur Sharma on ich.hr@ucl.ac.uk quoting job reference 1860908.
Closing Date: 3 April 2020
Latest time for the submission of applications: 23:59.

Interview Date: TBC

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