Dana-Farber Cancer Institute
The Oser Laboratory in the Division of Molecular and Cellular Oncology and the Department of Medical Oncology at the Dana-Farber Cancer Institute/Harvard Medical School focuses on identifying new therapeutic targets in small cell lung cancer (SCLC).
SCLC is a highly aggressive neuroendocrine cancer that is driven by loss of function (LOF) mutations in the tumor suppressor genes RB1, TP53, and NOTCH. It is also characterized by high expression of oncogenic neural/neuroendocrine transcription factors including ASCL1, NEUROD1, and POU2F3, which are dependencies in SCLC, but are undruggable. Our lab utilizes several approaches including CRISPR/Cas9-based functional screening and developing genetically-engineered mouse models of SCLC using CRISPR/Cas9 to identify novel ways to target LOF mutations in tumor suppressor genes and undruggable oncogenic drivers. Through our research, we seek to gain a more comprehensive understanding of SCLC tumorigenesis and identify new targeted therapy approaches for patients with SCLC.
• Dr. Oser is seeking a highly motivated and qualified postdoctoral candidate interested in pursuing several projects aimed at identifying new therapeutic targets for SCLC. The projects will have a dual focus on performing in vitro mechanistic studies in SCLC cell lines and in vivo studies using genetically-engineered mouse models of SCLC.
• The position will require a core foundation of molecular and cellular biology, biochemistry, tissue culture, and some basic training in mouse modeling and epigenetics.
• The successful candidate will be expected to lead and develop several independent projects.
• The candidate must have a MD, PhD or MD/PhD with several years of relevant experience in molecular biology with some research experience in cancer biology.
For more information, or to apply, please visit: https://careers-dfci.icims.com/jobs/18222/research-fellow/job
About Dana Farber:
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow’s physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.