University College London (UCL)

Research Fellow - Bioinformatician

University College London (UCL)

London, United Kingdom

Great Ormond Street Institute of Child Health


Research Fellow – Bioinformatician

Full Time

The appointment will be on UCL Grade 7. The salary range will be £35,965 – £36,945 per annum, inclusive of London Allowance.

We are seeking a talented and highly motivated computational biology postdoc to join the research group of Prof Adrian Thrasher and Dr Giandomenico Turchiano at the Great Ormond Street Institute of Child Health at UCL, within the Section of Molecular and Cellular Immunology ( ).

Gene therapies are showing an increasing success in clinical trials and they are continuously evolving towards new tools for genetic manipulation. Despite the great advantages, a better characterization of the genotoxicity effects is crucial for delivering safe and efficient therapies. We aim to apply existing and develop new techniques and analysis tools in order to characterize all the possible mutations and effects on primary cells and patient samples treated with lentiviral gene therapy and/or gene editing tools.

The successful candidate will contribute to the design and development of such techniques, leading the analyses and interpretation of the genotoxicity data. The post holder will work in an international and highly collaborative environment, benefiting from the expertise of both academia and industry in the field of gene editing, stem cell manipulation, genetics and computational biology.

This post is available for 24 months in the first instance.

Applicants must have PhD degree in a relevant subject. We are seeking a curious and talented researcher with a prime interest in gene editing and genomics. Candidates should have strong programming skills with a PhD in bioinformatics, computational biology, statistics or related genomic disciplines and should have prior experience with next-generation sequencing data, translational bioinformatics, data-mining of large scale genomic datasets and databases. Previous experience with RNA-seq, LM/LAM-PCR data analysis is a plus.

For further details about the vacancy and how to apply online please go to and search on Reference Number 1856838.

If you have any queries regarding the application process, please contact Madhur Sharma on quoting job reference 1856838.

Closing Date: 8 Feb 2020.

Latest time for the submission of applications: 23.59.

Interview Date: TBC.

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