UCL Research Department of Structural and Molecular Biology
The appointment will be on UCL Grade 7.
The salary range will be £35,965 – £43,470 per annum , inclusive of London Allowance.
An exciting opportunity has become available for a postdoctoral researcher to be part of a multidisciplinary consortium, working on protein CoAlation and antioxidant function of coenzyme A (CoA). Protein CoAlation is a reversible and widespread post-translational modification which occurs in eukaryotic and prokaryotic cells in response to oxidative and metabolic stress. The vast majority of CoAlated proteins (over 1000) were found to be metabolic enzymes, as well as proteins implicated in stress response and protein synthesis.
Protein CoAlation has been recently discovered in Prof. I. Gout’s laboratory and this research project is aimed at the identification and characterisation of deCoAlation enzymes (CoAredoxins) in bacteria and mammalian cells.
The work will provide critical information for understanding the mechanisms of protein CoAlation/deCoAlation and the role of CoA in balancing oxidative stress, redox state and cellular metabolism. This work will lay the foundation for delineating the role of protein CoAlation in health and disease.
This post is funded for 2 years 8 months in the first instance.
A PhD (or close to submitting thesis) in a relevant subject area is essential for the role, along with proven knowledge of research techniques and methodologies, related to the project: a) purification of endogenous and recombinant proteins, using various chromatographic approaches; b) knowledge of FPLC and HPLC analysis; c) molecular cloning and expression of recombinant proteins in bacterial, baculoviral and mammalian systems; d) culturing mammalian cells, transient and stable transfection, immunoprecipitation, Western blotting; e) setting up biochemical assays, especially in the field of redox biology.
Appointment on the Grade 7 scale is dependent on having been awarded a PhD; should this not be the case, the appointment will be made on the Grade 6B scale, (£31,479 – £33,194 per annum inclusive of London Allowance), with payment at Grade 7 being backdated to the date of final submission of thesis with corrections.
For further details about the vacancy and how to apply online please go to https://www.ucl.ac.uk/human-resources/working-ucl/jobs-ucl and search reference number 1827412.
For informal queries about the post, please contact Professor Ivan Gout, email: email@example.com . If you have any queries regarding the application process, please contact the Biosciences staffing team, firstname.lastname@example.org.
Closing Date: 21 October 2019
Latest time for the submission of applications: 23:59.
Interview Date: TBC
UCL Taking Action for Equality
We will consider applications to work on a part-time, flexible and job share basis wherever possible.
Our department holds an Athena SWAN Bronze award, in recognition of our commitment to advancing gender equality.