Research Associate – Miller lab (Fixed Term)
Cancer Research UK Cambridge Institute
This Post-Doctoral project will interrogate cancer-derived mechanisms of immune escape and identify novel immunooncology targets that will be validated using mouse models of pancreatic and ovarian cancer. In the Miller Lab at the University of Cambridge’s Cancer Research UK Cambridge Institute we are investigating the role of the tumour microenvironment in cancer using an array of technologies ranging from informatic analysis of human clinical data to proteomic and genomic analysis of in vitro and in vivo tumour microenvironment models (https://bit.ly/34A6tqO).
We are now looking to hire a competent and dedicated Immunologist with mouse modelling experience to join a dynamic team of scientists studying cell-cell communication within the tumour microenvironment.
You will develop an independent research project to investigate how cancer cells escape immune control using pancreatic and ovarian cancer cell and mouse models. We have performed immunogenomic and computational analysis of TCGA data as well as our own clinical cohorts and identified tumour-specific genomic alterations and transcriptional programmes that link to immune escape (Jimenez-Sanchez et al 2017 Cell, Jimenez-Sanchez et al 2018 BioRxiv/in revision in Nat Gen, Jimenez-Sanchez et al 2019 Cancer Research, Van den Eynden et al 2019 Nat Gen). You will develop a programme to interrogate these specific mechanisms as well as other informatically-identified IO targets to design novel combination treatment strategies such as targeted therapy and immune checkpoint blockade. You will help facilitate the continued development of our in vitro and in vivo platform for TME analysis, which includes tumour-immune co-cultures, cell-selective secretomics and proteomics (Gauthier et al 2013 Nat Meth), CRISPR modifications, scRNAseq, and protein-based barcoding technologies with multiplexing capabilities to resolve tagged cells and their co-localisation with immune cells in the TME using multiparameter IHF (4i) or imaging mass cytometry (Gill et al 2018, BioRxiv).
You should have a PhD in immunology or tumour-immunology. Candidates should have experience in animal (mouse) experimental procedures, isolation and phenotyping of cell subsets using flow cytometry, gene expression analysis (RNA-seq, sc-RNA-seq), IF microscopy and cell culture. You will have demonstrated creative and independent work and published within the field of immunology or cancer research. You will interact with wet and dry-lab members in a highly collaborative laboratory and contribute to the design and development of on-going research projects of other members of the group.
About CRUK CI: Europe’s top cancer charity, Cancer Research UK, has teamed with the University of Cambridge to create the world class Cambridge Institute (CI) situated on the Addenbrooke’s Biomedical Campus in Cambridge. The Institute’s research ranges from basic cancer biology through translational research to clinical application. The Institute currently houses over 350 researchers and contains new state-of-the-art research facilities. (https://bit.ly/2sDcu8U).
Fixed-term: The funds for this post are available for 3 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check.
To apply online for this vacancy and to view further information about the role, please visit :
If you have any questions about this vacancy or the application process, please contact HR-Shared@cruk.cam.ac.uk
The closing date is 3 February 2020, with the interview date TBC.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Please quote reference SW21838 on your application and in any correspondence about this vacancy.
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