The University of British Columbia (UBC)

Research Associate - Lorincz Lab

The University of British Columbia (UBC)

Vancouver, Canada

The Department of Medical Genetics at The University of British Columbia (UBC) invites applications for a full-time Research Associate position in the Lorincz Laboratory located in the Life Sciences Institute. The candidate must have strong understanding of genetics and molecular biological techniques, coupled with demonstrated bioinformatic skills. Experience in analyses of ChIP-seq and RNA-seq data would be an asset.

JOB SUMMARY

Project involves the study of the influence of specific histone modifications and enzymes that deposit these marks on expression of genes and retroelements in the germline and in early mouse development. Involves isolation of mouse germ cells and early mouse embryos as well as Embryonic Stem Cells culture systems and CRISPR-based genetic engineering. Conduct genome-wide analyses of epigenetic marks (ChIP-seq, whole-genome bisulphite sequencing, etc) and gene expression (RNA-seq) using high-throughput sequencing methods optimized for small amounts of starting material. Conduct bioinformatic analyses of data generated and write manuscripts describing results.

ACCOUNTABILITY

The Research Associate reports to Dr. Lorincz, the principal investigator, but is expected to operate independently on a daily basis. Results are reviewed and additional experiments outlined on a weekly basis. The Research Associate regularly interacts with members of the Lorincz lab regarding data generation and Bioinformatic pipelines and will be expected to interact with members from collaborating research labs. The Research Associate attends weekly meetings of all laboratory workers and presents results of the week’s work.

QUALIFICATIONS/ WORK PERFORMED

PhD in Genetics or related discipline with a proven track record in working with mouse models. Experience in germ cell and early mouse embryo isolation preferred.

Experience working with mouse Embryonic Stem Cells and differentiation systems along with CRISPR-based genetic engineering desirable.

At least 2 years of experience in the generation and analysis of next-generation sequencing data, including ChIP-seq and RNA-seq data from limiting numbers of cells.

Analyze next generation sequencing data, including whole genome, whole exome, RNA-seq, ChIP-seq and ATAC-seq data. Experience with various aligners (i.e BWA, TopHat, STAR) and ChIP-seq analysis tools (i.e FindPeaks, MACS, Broadpeaks) required.

Experience with various generic bioinformatics tools, including Samtools, UCSC genome browser, BLAT, clustalW, Circos, and ORFfinder recommended.

Excellent communication skills and the ability to work effectively in a fast-paced interdisciplinary environment.

Strong academic publication record in the field of epigenetics.

Strong writing skills. RA will write manuscripts relating to work conducted with Dr. Lorincz.

Proven track record of supervising and mentoring junior lab personnel required (e.g. research assistants, graduate trainees)

Evidence of success in obtaining research grants or fellowship funding an asset

CONSEQUENCES OF ERROR/IMPACT OF DECISIONS

Mouse work requires strong attention to detail and animal husbandry techniques. The analyses performed require strong background in bioinformatics. Errors in wet lab or dry lab work will result in delayed output of dataset analyses.

SUPERVISION RECEIVED

After initial training the Research Associate is expected to perform wet lab and bioinformatic analyses with only general supervision. The Research Associate discusses results and plans for additional analyses with principal investigator on a daily or bi-weekly basis.

SUPERVISION GIVEN

The Research Associate performs animal husbandry, molecular biology and bioinformatic analyses and teaches the application of these tools to other lab members, including graduate students and postdocs.

Review of applications will begin on July 31, 2022 and continue until the position is filled. Please submit your application to: Ada.Tsui@cw.bc.ca.

An application package should include a cover letter, CV with evidence of educational background, professional experience, and names and contact information of three referees.

This posting is for the UBC Vancouver campus in British Columbia, Canada.

Please refer to reference number NC-56338 during correspondence about this position.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

All qualified candidates are encouraged to apply; however Canadians and permanent residents will be given priority.

About UBC
The University of British Columbia is a global centre for research and teaching, consistently ranked among the top 20 public universities in the world. Since 1915, UBC’s entrepreneurial spirit has embraced innovation and challenged the status quo. UBC encourages its students, staff and faculty to challenge convention, lead discovery and explore new ways of learning. At UBC, bold thinking is given a place to develop into ideas that can change the world.

About UBC’s Faculty of Medicine
Our Vision: To Transform Health for Everyone.

Ranked among the world’s top medical schools with the fifth-largest MD enrollment in North America, the UBC Faculty of Medicine is a leader in both the science and the practice of medicine. Across British Columbia, more than 11,000 faculty and staff are training the next generation of doctors, health care professionals and scientists, making remarkable discoveries, and helping to create the pathways to better health for our communities at home and around the world.

The Faculty of Medicine – comprised of approximately 2,200 administrative support, technical/research and management and professional staff, as well approximately 650 full-time academic and more than 9,000 clinical faculty members – is composed of 19 academic basic science and/or clinical departments, three schools, and 24 research centres and institutes. Together with its University and Health Authority partners, the Faculty delivers innovative programs and conducts research in the areas of health and life sciences. Faculty, staff and trainees are located at university campuses, clinical academic campuses in hospital settings and other regionally based centres across the province.

About Vancouver
Vancouver is a dynamic, cosmopolitan and progressive city, consistently ranked as one of the top cities to live in the world. Canada’s third largest city has it all: sea, parks, mountains, beaches, and four seasons per year, including beautiful summers and mild, wet winters with snow in the mountains. It’s the perfect backdrop to your academic research.

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Position

Research Associate - Lorincz Lab