Imperial College London (ICL)

Research Associate

Imperial College London (ICL)

London, United Kingdom

Job Advertisement Title: Research Associate – UK Dementia Research Institute

Salary: £40,215 – £47,579 per annum

Location: White City and South Kensington campuses (London), and University of Edinburgh BioQuarter (Little France, Edinburgh)

Job Summary

Imperial College London and the University of Edinburgh are two of the world’s most highly ranked universities. This post will be associated with the UK Dementia Research Institute, part of the £290 million national UK Dementia Institute implemented across 6 major UK universities in 2017. 

A position is available for a post-doctoral Research Associate under the UK DRI Cross-Centre Postdoctoral Programme. This new initiative supports researchers co-supervised by PIs from different UK DRI centres. The position will focus on characterising the synaptic changes in human Alzheimer’s disease brain tissue. Initially, you will spend the first half of the project at Edinburgh University under the guidance of Professor Seth Grant conducting synaptome mapping of the brain tissue samples in collaboration with Dr Ricky Qiu. The second half of the project will be based at Imperial College London under the guidance of Dr Johanna Jackson and Professor Paul M. Matthews purifying synaptosomes and analysing their proteomic composition. The latter half of the project will be in collaboration with Dr Helen Huang and Professor Zoltan Takats.

The cross-centre nature of the post will require that the post holder is able to relocate between DRI centres in Edinburgh and London during the project lifetime.

We are substantially expanding research into the genomics and molecular neuropathology of Parkinson’s and Alzheimer’s disease. Our centres are addressing a range of questions concerning body-brain interactions to mediate the influences of environment and lifestyle on disease risk. Scientists in the UK DRI are pursuing fundamental neuroscience questions with a highly translational focus, working in vitro, with preclinical models and in human studies. The environment is highly collaborative and interdisciplinary. 

There is an opportunity to rapidly improve our understanding of the processes in neurodegenerative diseases by exploitation of recent, transformative advances in multi-omics, imaging and computational methods. Together, these enable simultaneous consideration of cellular events occurring across multiple dimensions and at multiple scales. Knowledge of the genetic basis of disease is rapidly outpacing our ability to interpret it and targeted data collection is required to enable data integration from genetic to cellular scales. Our goal is to create a comprehensive molecular cell atlas of Alzheimer’s disease in the brain through a UK DRI Multi-‘omics Atlas Project (MAP).

Duties and responsibilities

You will be a dynamic, creative and independent scientist interested in pursuing questions deeply. Prior experience in proteomics methods and a strong background in neurobiology will be assets, as will familiarity with related bioinformatics approaches.

You will work with PIs across the collaboration to

  • Develop novel research concepts, approaches and tools
  • Lead the implementation of these novel approaches and tools
  • Integrate multiple methods as part of well-designed research plans that efficiently address and resolve fundamental research questions
  • Publish and present research findings in a timely manner

Essential requirements

You will have an advanced academic qualification (PhD or equivalent) in a relevant discipline with evidence of practical experience in molecular biology, proteomic and cellular. Practical experience with relevant molecular biological and proteomics methods and cell or biological tissue and data management.

The cross-centre nature of the post will require that you are able to relocate between DRI centres in Edinburgh and London during the project lifetime.

Further Information


This post is offered full time and initially for a fixed term until 31 March 2023.

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £35,477 – £38,566 per annum.


Should you have any queries please contact Dr Johanna Jackson (johanna.jackson@imperial.ac.uk)

Closing date: 12/07/2020

To apply, visit www.imperial.ac.uk/jobs and search by the job reference MED01875.

Please apply via recruiter’s website.