Imperial College London (ICL)

Research Associate

Imperial College London (ICL)

London, United Kingdom

Research Associate


Salary: £40,215 per annum


Location: Hammersmith campus (located in East Acton)


Job Summary


We are seeking a research Associate to work in the Sarkies Lab at the Medical Research Council (MRC) London Institute of Medical Sciences, funded by Worldwide Cancer Research. 


Recently, the Sarkies laboratory has shown that DNA methyltransferases have an off-target effect whereby they introduce a toxic form of DNA damage, 3meC, into DNA. This requires the activity of a specialised repair enzyme, ALKB2, and as a result, DNA methyltransferases co-evolve with the enzyme ALKB2 across a range of species (Rosic et al., Nature Genetics, 2018). 


Duties and responsibilities



You will explore the implications of this finding for cancer biology. In particular, we aim to test whether the levels and activity of DNA methyltransferases in cancer cells are shaped by the expression of ALKB2, by modulating the levels of both ALKB2 and DNA methyltransferases in cancer cells using CRISPR-Cas9 mediated genome editing. 


Essential requirements


The ideal candidate will have experience in cell culture, ideally using cancer cells, CRISPR-Cas9-mediated genome editing and experience in either DNA damage or epigenetics. You will gain the opportunity to work in a dynamic laboratory at the interface between evolution and epigenetics and will be able to spearhead new applications of this approach to human disease. You will be able to work in a highly collaborative and innovative environment both within the Sarkies lab and across the MRC London Institute of Medical Sciences, a core-funded institute with excellent links to Imperial College London. 



Further information



To apply please visit: https://www.imperial.ac.uk/jobs/description/MED01663/research-associate


The post is full time and fixed-term from 01st May 2020 until 30th April 2023.


Candidates who have not yet been officially awarded their PhD will be appointed as Research Assistant within the salary range £35,477 – £38,566 per annum.


The applicants should contact Dr Peter Sarkies (For informal enquiries please contact Dr Peter Sarkies (p.sarkies@lms.mrc.ac.uk)


For technical issues when applying online please email recruitment@imperial.ac.uk.


Please apply via recruiter’s website.