£37,486 – £46,499 plus benefits
Applications are invited for two Research Associates in infectious diseases to join the Department of Life Sciences at Imperial College London. The successful candidates will be joining Professor Frankel’s Group based in the MRC Centre for Bacteriology Microbiology and Infection (CMBI), located in the Flowers Building, South Kensington Campus. The CMBI is a centre of excellence housing several groups studying bacterial pathogenesis, secretion systems, virulence and colonisation factors, gene expression, bacterial cell walls, toxins and biofilms.
Enteric bacterial infections and inflammation are intimately linked with metabolism and the microbiome. Recent studies illustrated the fluidity of the pathogenic state, which could be tilted towards commensalism by changes to diet and the composition of the microbiota. Successful candidates will use the natural mouse pathogen Citrobacter rodentium to model pathogen-microbiome-diet interactions (Cell Metabol. 26 (2017), 738-752.e6; Cell Reports 20 (2017), 2201-2214).
Candidates interested in infection, inflammation and metabolism (e.g. cholesterol homeostasis) and the pathogenic/commensal interface are encouraged to apply.
Duties and responsibilities
The successful candidates are expected to perform the outlined experiments to a high standard. In particular, the candidates are expected to:
• Perform standard scientific techniques including cell culture, infection and in vivo mouse procedures
• To perform detailed inflammatory profiling of infection
• To conduct multiomic studies (g. metagenomics, transcriptomics and metabolomics) including large scale data analysis
• To conduct bioinformatic analysis
• To closely collaborate with specialists in ex vivo infection models (e.g. organoids)
• To ensure the validity and reliability of data at all times
• To present findings to colleagues and at conferences
• To write up the findings for submission to refereed journals
• A PhD degree (or equivalent) in Molecular Cell Biology, Infection, Microbiome
You must be able to demonstrate:
Experience in the following:
• Cell biology of infection and molecular biology
• In vivo mouse work (a Home Office personal animal licence is desirable, but not essential)
• Bioinformatics/data analysis
Knowledge of the following:
• Statistical and image analyses
• Pathogen host interactions
You must also be able to demonstrate:
• The ability to work as part of a team and to be open minded and cooperative
• The ability to develop and apply new concepts and have a creative approach to problem solving
• Excellent verbal and written communication skills
• The ability to organise your own work with minimal supervision and prioritise in response to deadlines.
This is a full time, fixed-term position from 1st October 2019 until 1st November 2021. Two positions are available.
*Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £34,397 – £37,486 per annum.
Informal enquiries can be made directly to Professor Gad Frankel, Tel +44 20 7594 5253; email: email@example.com
For technical queries when applying online, please contact firstname.lastname@example.org
To apply, please visit: https://www.imperial.ac.uk/jobs/description/NAT00496/research-associate
Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.