Harvard Medical School (HMS)

Research Associate

BCMP Center for Macromolecular Interactions

Boston, MA, United States

Protein Scientist Position at the Center for Macromolecular Interactions

The Center for Macromolecular Interactions (CMI) in the department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School (HMS) has a mission to enhance basic research in the HMS community by providing scientific consultation, training and access to shared biophysical instruments for the characterization and analysis of macromolecules and their complexes. The CMI will be offering yeast display antibody fragment (VHH, nanobody) selection and production services in the coming year and is looking for an enthusiastic protein scientist/combinatorial biologist to take a central role in this effort.

Job Description

  1. Establish a yeast surface display nanobody production service at the CMI.
  2. Develop a workflow for yeast selection, validation and nanobody production
  3. Work closely with CMI customers in completing nanobody selection and production projects
  4. Collaborate with the lab of Andrew Kruse and others to develop next generation yeast display antibody fragment libraries. 
  5. Interact directly with CMI users of biophysical instrumentation by providing training and advice, especially in the area of protein production, protein purification and yeast display.
  6. Assist the CMI Core Director in managing the facility.
  7. Maintain excellent records of multiple concurrent projects.


  • Ph.D. in a field related to protein biochemistry, cell biology, or structural biology with expertise in protein production and purification. Yeast surface display, protein engineering, and/or antibody production experience, preferred.
  • Experience operating and maintaining laboratory instrumentation. Proficiency operating biophysical instrumentation including equipment for SPR, BLI, ITC, MST, CD, DSF, and/or light scattering is a plus.
  • The candidate should be highly motivated, detail-oriented, and have the ability to work independently and to collaborate with a diverse group of core staff and users. 

To apply please submit a cover letter and CV to the director, Dr. Kelly Arnett, at cmi@hms.harvard.edu. Additional information about the CMI can be found at the core website (http://cmi.hms.harvard.edu).


Apply with CV and Cover Letter

Must be a .doc, .docx, or .pdf file and no larger than 1MBMust be a .doc, .docx, or .pdf file and no larger than 1MB

Research Associate