University of Cambridge

Research Associate (Fixed Term)

University of Cambridge

Cambridge, United Kingdom

Research Associate (Fixed Term)
Department of Medicine
£32,236-£39,609
Reference: RC18861

We invite applicants for a three-year post-doctoral Research Associate post to undertake computational data analysis and potential related wet-lab work in the group of Dr Helle Jørgensen (http://www.med.cam.ac.uk/jorgensen/) at the University of Cambridge. This project is a collaboration with Dr Mikhail Spivakov (lms.mrc.ac.uk/research-group/functional-gene-control/).

We investigate the regulation of cell plasticity and heterogeneity in vascular biology and disease. The group has a particular focus on proliferative responses, which has direct implication for the development of cardiovascular disease. We previously demonstrated a selective response of very few cells using clonal lineage tracing in animal models (see Chappell et al, PMID: 27682618) and used single cell RNA-sequencing to identify variable expression of disease-related genes that we propose underlie the observed functional heterogeneity (Dobnikar/Taylor et al, PMID: 30385745).

We are now seeking an individual to join our team to study the transcriptional networks regulating the selective activation of some vascular smooth muscle cells. The project will involve analysis and generation of functional genomic datasets, including single-cell RNA-seq and ATAC-seq, to identify candidate mechanisms regulating activation of proliferation for testing. The ideal candidate will have experience in both data analysis and experimental data generation.

Essential skills:

• PhD in biological science or a numerical discipline (provided prior experience working in a biological context)
• Demonstrated experience in functional genomics data analysis
• Strong understanding of gene regulation
• Experience in transcriptional profiling, ideally using single cell technologies
• Experience with statistical analysis
• Demonstrated scripting experience in R or python
• Proactive attitude and drive
• Strong communication skills and the ability to work effectively as part of an interdisciplinary team
• Attention to detail and ability to multi-task
• Experience in writing scientific manuscripts
• Experience presenting ideas and findings

Desirable skills:

• Experience with Seurat, Monocle and/or single cell RNA-seq analysis packages
• Strong publication record
• Knowledge on cardiovascular biology
• Experience with molecular and cell biology lab work
• Prior knowledge of animal models

The position is available immediately. Informal enquiries should be directed to Dr Helle Jørgensen (tel. 44 (0)1223 762581, e-mail hfj22@cam.ac.uk).

The Jørgensen group is a part of the Cardiovascular Medicine Division at the Department of Medicine. We are located at the Addenbrooke’s Biomedical Campus with access to state of the art facilities and a stimulating scientific environment. The group is a member of the British Heart Foundation Regenerative Medicine Centre and the Cambridge Centre for Research Excellence and benefit from the unique opportunity to interact with other members of those partnerships at annual Centre meetings.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check.

To apply online for this vacancy and to view further information about the role, please visit:
http://www.jobs.cam.ac.uk/job/21219/
Closing Date – 19th May 2019

Please ensure that you upload your Curriculum Vitae (CV) and a covering letter in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager

Please quote reference RC18861 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Please apply via recruiter’s website.

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