University of Cambridge

Research Associate Bioinformatician

University of Cambridge

Cambridge, United Kingdom

Research Associate (Bioinformatician) (Fixed Term)
Cancer Research UK Cambridge Institute
£32,236-£39,609
Reference: SW18919

As part of the pioneering Integrated Medicine Program (ICM) currently running in the CRUK Cambridge Centre, we aim to recruit a Research Associate (Bioinformatician) to be part of an ambitious project that will integrate in real time multiple data sources from different cancer types with the goal to achieve better clinical treatment decisions.

Specifically, the successful candidate will work with datasets from whole genome sequencing (WGS), whole transcriptome sequencing (RNA-SEQ) and image analysis from breast cancer tumours. He/she will design procedures to extract the most relevant information from these datasets, develop statistical models for data integration1-2 and design visualization tools to summarise the tumour status at diagnosis. Other data sources, like ctDNA or sequential images will need to be incorporated to produce information for monitoring treatment response3, and information from patient-derived tumour xenografts (PDTXs) avatars will be integrated to offer therapeutic options in the case of metastatic disease4.

This project will require the development of novel statistical methods, therefore we are looking for a candidate with a PhD in Statistics, Computational Biology or a related discipline. The work will be carried out within a multidisciplinary laboratory that includes genomic, biological, computational and clinical scientists. Teamwork and ability to communicate ideas and results is required. Advanced knowledge of R is also needed.

The position will be integrated in the Caldas Laboratory at the CRUK Cambridge Institute (CRUK-CI).

As mentioned above, this post-doctoral position will be part of the Integrated Cancer Medicine (ICM) programme. The overarching objective of ICM is to deliver a revolutionary new treatment paradigm for cancer patients. This concept envisages the integration of clinical, laboratory, mathematical and computational science and technology to the point where all patient data is used maximally to guide optimal treatment decisions. The ICM leverages our expertise in cancer genomics, ‘liquid biopsies’ (detecting tumour DNA in the blood), molecular imaging and 3D tumour mapping to generate Data Streams that simultaneously report the functional biology of tumours among cancer patients receiving active treatment. These data will then be integrated using innovative Cambridge-invented mathematics and statistical algorithms with the goal of charting precision medicine approaches for all patients.

Fixed-term: The funds for this post are available for 2 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

To apply online for this vacancy and to view further information about the role, please visit:
http://www.jobs.cam.ac.uk/job/21281/
Closing date: 24 May 2019

Please ensure that you upload a covering letter and CV in the Upload section of the online application.

If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

The closing date for applications is 24 May 2019.

Any queries regarding this post should be directed to Oscar Rueda by e-mail at oscar.rueda@cruk.cam.ac.uk.

Please quote reference SW18919 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Please apply via recruiter’s website.

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