Wellcome Trust Sanger Institute

Research Assistant - Cellular Generation and Phenotyping

Wellcome Trust Sanger Institute

Cambridge, United Kingdom

An opportunity has arisen for two talented individuals to support the Cellular Generation and Phenotyping team (CGaP) at the Sanger Institute.

At Sanger, we appreciate the importance of achieving work-life balance and support this with a number of family and carer-friendly policies. We will equally consider applications from candidates working either full or part time hours (minimum 25 hours per week for this position). Please specify your preferred working hours and pattern in your application.
• Would you love to work in a high throughput or process driven setting?
• Are you organised, meticulous and love process improvement?
• Do you thrive in a multi-disciplinary team, working together to tackle complex issues?

If you said yes to the above questions, then this could be the job for you.
Please see the following job overview for each role:

Role 1:
You will join a multi-disciplinary team who are working as part of the Human Cancer Model Initiative to generate one of the largest cancer organoid biobank in the world. Approximately 1,000 human cancer cell lines are available worldwide as a useful resource for cancer research. However, poor disease representation, insufficient numbers to capture the genetic diversity of cancer and lack of comparison to normal reference samples limit their use. Novel cell culturing methods such as organoid derivation will revolutionise our ability to derive new models and have the potential to overcome these limitations.

This role will include processing human tumour samples to derive organoid models, expansion and banking of organoids and ensuring Quality Controls are met. You will also be expected to co-ordinate the transfer of samples to and from the faculty team, troubleshoot issues and identify areas for process improvement.

Role 2:
You will be working as a part of a team performing genome-wide CRISPR-Cas9 knockout screens on cancer and induced pluripotent stem (iPS) cell lines to investigate gene essentiality on an individual patient level.

This role will include the large-scale culture of cancer and iPS cell lines, transduction of these cell lines with lentiviruses and quality control analysis using a range of assays such as flow cytometry and viability assays. As part of the lab work, you will be required to contribute to troubleshooting issues, proactively working as a team to deliver the project and report progress to the faculty team.

About us:
CGaP is a core facility, responsible for providing cell biology resource and expertise to the wider institute. We do this by running multiple, high throughput projects in partnership with faculty teams across the Institute. Our current portfolio of projects includes genome wide CRISPR screens, iPSC derivation and differentiation, The Human Cell Atlas and Organoid Derivation. Our role is to support the institute in its aims and for that we continually strive to remain at the forefront of cutting edge research. Namely translating academic research into large-scale projects, which push the boundaries of our understanding, allowing the Sanger to remain a world leader in genome research.

We will provide you with all the appropriate training for you to fulfil your role and offer you a career pathway so you can continue to progress and learn new skills. We also support all staff to take part in department and institute wide initiatives.

This is an excellent opportunity for a motivated and adaptable individual to join the team in delivering high quality science.

Essential Skills
• Degree in Biological Sciences or equivalent experience
• Experience in a life science laboratory
• Good knowledge of cell culture techniques
• Excellent written and oral communication skills
• Excellent organisational skills, able to plan and prioritise effectively
• Proven experience of working within a team
• Ability to keep good up-to-date records with attention to detail
Ideal Skills
• Experience of cell culture
• Experience of running cell based assays

Other information
Please include a covering letter with your application describing how you meet the essential criteria for the role.
Closing date: 1st March 2020

About Us
The Wellcome Sanger Institute is a world leading genomics research centre. We undertake large-scale research that forms the foundations of knowledge in biology and medicine. Our findings are used to improve health and to understand life on Earth. Find out more at www.sanger.ac.uk or follow us on Twitter, Facebook, LinkedIn, Youtube and on our Blog.

Our campus
Set across 130 acres, just outside of Cambridge, The Sanger Institute is located on the stunning Wellcome Genome Campus. Home to some of the world’s foremost institutes and organisations in genomics and computational biology, committed to delivering life-changing science with the reach, scale, and creativity to solve some of humanity’s greatest challenges.

Our benefits:
There’s an attractive benefits package on offer at the Genome Wellcome Campus. We appreciate the importance of achieving work-life balance and support this with a number of family and carer-friendly policies. Plus a flexible working policy for those who may wish to amend their working pattern or arrangement.
As well as the usual benefits you would expect, we go much further:
• 25 days annual leave (extra 1 day to a maximum of 30 days for every year you work)
• Auto-enrolment into a generous Group Defined Contribution Pension Scheme, with enhanced company contribution (for more information, see our Pensions page)
• Up to 2 days annual paid volunteering leave
• Up to 10 days paid Emergency Carers Leave per year
• Family friendly environment including options for flexible and part-time working, an on-site Workplace Nursery salary Sacrifice Schemes for pre-school children and Summer holiday club
• Life Assurance Cover and a Group Income Protection Scheme (if on a contract of 12 months or more)
• Enhanced maternity leave and parental leave
• Access to substantial number of courses and training events onsite
• Private Healthcare Scheme (after 6 months service)
• Eyecare and Dental payment plans
• Concessions and discounts from our corporate perks site

Being part of the Genome Wellcome Campus you will be part of the beautiful working environment with an impressive range of benefits, services and facilities also including:
• Free bus service to and from Campus, covering various routes around Cambridge, Saffron Walden and surrounding villages
• A car-share initiative
• Free parking
• A number of on-site venues where you can meet, eat and socialise with colleagues
• A thriving Sports and Social Club which provides members with subsidised access to a gym, tennis courts, sports hall, fitness classes and a vibrant social calendar of events

Find out more about our Genome Wellcome Campus.

We hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Please apply via recruiter’s website.