Guangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL)

Recruitment of Faculty for Guangzhou Regenerative Medicine and Health Guangdong Laboratory

Guangzhou Regenerative Medicine and Health Guangdong Laboratory

Guangzhou, China

Introduction
Guangzhou Regenerative Medicine and Health Guangdong Laboratory, or GRMH-GDL, was founded as one of the first provincial laboratories on 22 December 2017. The laboratory are dedicates to 4 directions: frontier theoretical and technological research on stem cells and regenerative medicine, research on remodeling of tissues and organs, precision medicine & preclinical study, and research on the application of regenerative medicine. The laboratory is aiming to develop the reserves for constructing National Laboratories in Guangdong Province and operated as a public institution. GRMH-GDL offer 1. Internationally competitive remuneration and generous start-up package. 2.Exceptional research platform and a variety of development opportunities for Principal Investigator and Associate Professor:

General Pain Institute
About our center:
General Pain Institute (GPI) is one of the scientific research centers in GRMH- GDL and headed by Dr. Horace H. Loh, who is an Academician of the Academia Sinica in Taiwan, China, Regents Professor and former Head of the Department of Pharmacology, University of Minnesota.

Research Directions:
GPI focuses on pain-related research which including: 1) to discover new targets for treating pain and develop new, effective and safe analgesic agents by revealing the physiological and psychological mechanisms of pain; 2) to study the side effects of addiction and abuse of the current analgesic agents, and to reduce the addiction and drug dependence while retaining the original analgesic effects; 3) to investigate the mechanisms of pathogenesis and develop drugs for other neurological diseases; 4) try to combine the traditional drug treatment with regenerative medicine to explore the new therapy methods for neurological diseases.

Position and Qualifications:
Principal Investigator and Associate Professor:
1. Must have a Ph.D.in cell biology, neurobiology, pharmacology, molecular biology, bioinformatics with strong research experiences and accomplishments.

2. PI should no more than 45 years old and AP should no more than 40 years old. (If the applicants show great excellence, the age limitation can be flexible.)

Applications need to include:
Please submit a full CV, two-page summary of research interest in the future, two letters of recommendation and other documents that can prove academic qualifications to the email: zheng_hui@gibh.ac.cn and/or miao_xiaoli@grml-gdl.cn

Center of Chemistry and Chemical Biology
About our center:
Center of Chemistry and Chemical Biology (CCCB) is dedicated to solving key problems in chemistry and chemical biology with frontier technologies. Our center will establish and develop the most cutting-edge technologies, including automatic synthesis, high-throughput screening, AI-assisted drug design, machine learning for reaction prediction and synthetic route design. With the aims to set the trends of advanced research and the direction of interdisciplinary development, CCCB is committed to build an open platform for knowledge exchange, science innovation, project collaboration and talents training.

CCCB is seeking highly motivated and experienced scientists with proven track record in the fields of organic synthesis, medicinal chemistry, chemical biology, computational chemistry and machine learning to fill up the Principal investigators, Associate Professor positions.

Research Directions:
1. Organic chemistry methodology development

2. Automatic synthesis

3. High-throughput screening and parallel synthesis

4. Medicinal chemistry research for development of chemical probes and new medicines

5. AI-assisted drug design, machine learning for reaction prediction and synthetic route design

6. Development of technical platforms for new therapeutic modalities, DNA encoded library, proteolysis targeting chimera (PROTAC)

7. Development of novel drug delivery systems.

Qualifications:
1.PhD in organic chemistry, medicinal chemistry, chemical biology, bioinformatics, computational chemistry or other related fields.

2.Experience in above disciplines with proven track record of publications in scientific journals.

3.Proven ability to solve critical business and scientific problems.

4.Good communication skill

5.Full professional proficiency in English.

Applications need to include:
A cover letter, curriculum vitae, three reference letters and future research plan should be sent to liao_kuangbiao@grmh-gdl.cn with subject of “Position and Name”.

The Advanced Institute for Regenerative Medicine
About our center:
The Advanced Institute for Regenerative Medicine (AIRM) is a joint research institute of the GRMH-GDL and The Chinese University of Hong Kong. The Advanced Institute focuses on basic research in stem cells and regenerative medicine, aiming to build a world-class scientific research center, and strives to become an important part of the world-class science and technology innovation center in Guangdong, Hong Kong and Macau.

Research Topics:
1. Orthopaedic research as a study of the biological activities underlying the development, growth, function, and health of skeletal tissues.

2. Functional genomics and epigenetic regulation of development in health and diseases.

3. Musculoskeletal disorders, including osteoporosis, osteonecrosis and osteoarthritis.

4. Translational application of mesenchymal stem cells for musculoskeletal disease therapy.

5. Molecular control of pluripotent stem cells; Gene therapy and cell therapy.

6. Micro/nano biofabrication based on 3D bioprinting and microfluidic techniques for regenerative medicine applications, including organ regeneration, regulation of stem cell fate and differentiation.

Position and Requirements:
Associate Professors (12 openings) should have:
1. a PhD, MD, or DVM degree or its equivalent in biological and biomedical sciences or related disciplines;

2. solid postdoctoral research experience in equivalent field(s) for at least two years, and oversea study/research experience is preferred;

3. a competitive track record of research and publication in top peer-reviewed scientific journals in one or more related areas;

4. expertise in using cutting-edge technologies in biochemistry, molecular biology, cell imaging, bioinformatics, genomics, molecular genetics, stem cells, transgenic animal and imaging, animal models of human diseases, biomaterials, 3D bioprinting, and/or microfluidics in their studies;

Applications need to include:
1. A detailed CV that includes basic personal information, educational and professional background, research experience, mobility experience, major academic achievements/awards, list of publications/patents, and copies of relevant certificates).

2. Personal statement that highlights the candidate’s research experience and interests.

3. At least three academic or professional reference letters.

All applications should be sent to: Dr KONG Ling, kong_ling@grmh-gdl.cn; Dr WANG Yaofeng, wang_yaofeng@grmh-gdl.cn.

Center of Cell Lineage and Atlas
About Our Center:
Center of cell lineage and atlas (CCLA) is one of the founding research center at Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL), aiming to deciphering the principles underlying cell fate transition and intercellular interaction, probing the regulatory nature of cell lineages in development and disease. CCLA is seeking outstanding individuals for positions of full-time Professor and Associate Professor in diverse disciplines of stem cell biology and translational medicine.

Research Directions:
1. Technology development and application of single-cell omics.

2. Super-resolution imaging or in toto imaging.

3. Cell migration and self-organization on development.

4. Genetic and single-cell lineage tracing for tissue organization .

5. Epigenetic regulation in cell fate determination.

6. Embryonic development and in vitro organogenesis.

Qualifications:
1. PhD in cell biology/molecular biology/developmental biology/genetics/bioinformatics or related field, with academic or industrial experience on stem cell biology, single-cell study and/or tissue lineages is preferred.

2. A proven track record of publications in high quality scientific journals.

3. Ability to work both independently and collaboratively, to lead multidisciplinary teams, with strong sense of responsibility

Applications need to include:
Please submit a full CV, two-page summary of research proposal, and other documents that can prove academic qualifications to the email: ccla@grmh-gdl.cn.

The Center for Systems Biology
About Our Center:
The Center for Systems Biology in Development and Cancer (SBDC), as part of GRMH-GDL, addresses tissue anlage formation, cell fate determination, and
differentiation. In-depth molecular approaches intend to explore mechanisms that promote invertebrate to vertebrate adult morphogenesis and organogenesis using high-resolution mapping of cell lineage and cell assembly leading to functional organs. State-of-the-art technologies will implement scaffolds and optimised culture conditions for tissue engineering and organ regeneration.

SBDC also addresses inflammation and cancer. Among other themes, cancer stem cells/tumor initiating cells, and tumor heterogeneity will be explored through genetic, epigenetic and metabolic approaches. Refractoriness to treatments, that drives recurrence will be unravelled to identify the “Achilles’ heel” of tumors.

SBDC is seeking outstanding individuals for positions of Research Professor and Associate Professor in the above areas.

Applications need to include:
Candidates should submit a curriculum vitae, a statement of expertise and research interest, pdfs of the three most significant publications and three reference letters to: bchtjp@nus.edu.sg


We also have Postdoctoral Fellows/Research Associates available at the following centers:
-————Reprogramming and Regeneration Laboratory
Pia Cosma’s laboratory (http://piacosmalab.com/) at GRMH-GDL (http://en.grmh-gdl.cn) investigates the mechanisms controlling somatic cells reprogramming and tissue regeneration. Using super resolution microscopy, the group has identified how chromatin fiber assemble in somatic and stem cells (Ricci et al., Cell 2015; Otterstorm et al., NAR 2019). Ongoing research is to study how chromatin fibers of somatic cells chage to overcome epigenetic barriers to gain pluripotency.

Postdoctoral positions
1.In stem cell biology and tissue regeneration

Requirements: Phd in Biology, Biomedicine, or related disciplines.

Project: To set up efficient cell therapy approaches to regenerate the retina in large animals.

Technical skills needed: Experience in stem cell biology and/or animal and tissue biology. Desirable: genome editing and genomics.

2. In computational analysis of super resolution imaging data

Requirements: Phd in Biophysics, Mathematics or related disciplines. Dry and/or wet experience.
Projects:
1.-To develop new methods for analyzing super resolution imaging data to study mechanisms of in culture and in vivo reprogramming.
2.- To apply machine learning to analyze super resolution imaging data to identify novel nuclear structures.

Technical skills needed: Matlab, Python, R programming languages. Desirable: imaging analysis, machine learning, spatial modelling and statistics.

Application
CV,motivation letter and 2-3 reference contacts sent to pia_cosma@grmh-gdl.cn


The Center for Systems Biology


General Pain Institute


Center of Chemistry and Chemical Biology


The Advanced Institute for Regenerative Medicine


The Center of Cell Lineage and Atlas

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Recruitment of Faculty for Guangzhou Regenerative Medicine and Health Guangdong Laboratory