CRUK Beatson Institute for Cancer Research

Protein NMR Senior Scientist

Beatson Institute for Cancer Research

Glasgow, Scotland, United Kingdom

Protein NMR Senior Scientist, Beatson Drug Discovery Unit

Salary Range £24,776 – £41,536 , depending on experience

The Drug Discovery Unit at the CRUK Beatson Institute in Glasgow, is a Cancer Research UK funded team of highly experienced scientists engaged in discovering and developing cancer drug treatments of the future. The aim of the Unit is to work closely with local cancer experts to maximise the opportunity to develop new and innovative therapies that strike at the core of cancer pathology. Using state of the art screening, advanced structural biology, industry standard medicinal chemistry and complex biological modelling systems, the Drug Discovery team at the Beatson is tackling some of the most challenging targets in cancer biology today.

We currently have an exciting opportunity as a consequence of the expansion in our drug discovery portfolio. If you are a highly skilled, enthusiastic individual who takes an innovative and proactive approach to research challenges, then we would like to hear from you.

We are looking for a talented and motivated Protein NMR scientist who will take a central role in our structural sciences team. The ideal candidate should have extensive hands-on experience with high-resolution protein NMR spectroscopy, including 1D & 2D data interpretation along with experimental set-up and problem solving. The Beatson Drug Discovery Unit is equipped with state of the art NMR spectrometers to support medicinal chemistry (Bruker NEO 400) and for fragment screening and protein NMR (Bruker NEO 600 with a CryoProbe). In addition, we are also members of the Scottish High Field NMR Centre Consortium at the University of Edinburgh which enables us to access their recently upgraded 800MHz NMR spectrometer.

Playing an influential role in our drug discovery projects, you will work collaboratively with all teams (biophysicists, protein scientists, crystallographers, biologists and chemists) at the Beatson and wider CRUK network to help formulate innovative and forward thinking approaches towards tackling exciting and challenging drug target classes.

The role requires you to develop and use novel NMR & other biophysical assays to characterise protein ligand interactions, applying these to medicinal chemistry-driven projects at all stages from fragment-based hit identification through to lead optimisation. The quality data that you produce will be critical, helping teams form an understanding of both the mechanism of action of our molecules and the target biology.

In addition, you will contribute to the development of the biophysics discipline by identifying and driving improvements and innovations that advance drug discovery projects.

Skills & Experience:

• PhD in Biochemistry or a related discipline with strong skills in protein NMR assignment.
• Experience of NMR for measuring protein-ligand interactions is highly desirable.
• Experience of determining solution structure of protein:ligand complexes would be a distinct advantage.
• Small molecule NMR for structure and purity determination is required.
• Experience of additional biophysical techniques (e.g. ITC & SPR) along with a solid understanding of protein science and enzymology is also desirable.
• Experience of working in a drug discovery environment where structural and biophysical studies are central to the progression of medicinal chemistry strategies would be an advantage.
• Excellent communication and collaborative approach, including experience of working as part of multidisciplinary team.
In return, we offer an inspiring, supportive and multi-disciplinary environment in a state-of-the-art, purpose built laboratory in which to further enhance your skills and knowledge of structural sciences, biophysics, cancer biology and drug discovery; providing you the opportunity to make a real difference to the lives of cancer patients.

All applications must be made via our website,

Informal enquiries are welcome and should be addressed to Dr Justin Bower; (Joint Head of Beatson Drug Discovery Unit)

Closing date for applications is 21 June 2019

Please apply via recruiter’s website.