Protein Crystallographer Senior Scientist, Beatson Drug Discovery Unit
18 month Temporary Position
Salary Range £24,776 – £41,536, depending on experience
The Drug Discovery Unit at the CRUK Beatson Institute in Glasgow, is a Cancer Research UK funded team of highly experienced scientists engaged in discovering and developing cancer drug treatments of the future. The aim of the Unit is to work closely with local cancer experts to maximise the opportunity to develop new and innovative therapies that strike at the core of cancer pathology. Using state of the art screening, advanced structural biology, industry standard medicinal chemistry and complex biological modelling systems, the Drug Discovery team at the Beatson is tackling some of the most challenging targets in cancer biology today.
We currently have an exciting opportunity as a consequence of the expansion in our drug discovery portfolio. If you are a highly skilled, enthusiastic individual who takes an innovative and proactive approach to research challenges, then we would like to hear from you.
We are looking for a talented and motivated protein crystallographer who will take a central role in our structural sciences team. The ideal candidate should have extensive hands-on experience of crystallisation methods and a proven track record in solving crystal structures.
Playing an influential role in our drug discovery projects, you will work collaboratively with all teams (biophysicists, protein scientists, crystallographers, biologists and chemists) at the Beatson and wider CRUK network to help formulate innovative and forward thinking approaches towards tackling exciting and challenging drug target classes.
The role requires you to establish robust crystallisation systems for important targets and to use these to generate structures of protein/small molecule complexes that inform our structure-based drug design efforts. The quality data that you produce will be critical, helping teams form an understanding of both the mechanism of action of our molecules and the target biology.
Skills and Experience :
• Ph.D. in protein crystallography.
• Proven and demonstrated skills in crystallisation of challenging protein targets.
• Competent in the use of all standard macromolecular crystallography software.
• Experienced in synchrotron data collection, data processing, model building and refinement.
• An understanding of both protein structural biology and small molecule chemistry is an advantage.
• Experience with protein expression and purification along with a solid understanding of biophysical techniques (e.g. ITC or SPR) is also desirable.
• Additional experience within the pharmaceutical industry or an equivalent translational research environment would be an advantage.
In return, we offer an inspiring, supportive and multi-disciplinary environment in a state-of-the-art, purpose built laboratory in which to further enhance your skills and knowledge of structural sciences, biophysics, cancer biology and drug discovery, providing you with the opportunity to make a real difference to the lives of cancer patients.
All applications must be made via our website, http://www.beatson.gla.ac.uk/Careers/Drug-Discovery/
Informal enquiries are welcome and should be addressed to Dr Justin Bower; firstname.lastname@example.org (Joint Head of Beatson Drug Discovery Unit).
Closing date for applications is Friday 21 June 2019