GlaxoSmithKline plc. (GSK)

Principal Scientist – Antibody Developability

GlaxoSmithKline plc. (GSK)

Stevenage, United Kingdom

GSK is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.

Biopharm Discovery is a department dedicated to the discovery of novel and effective biopharmaceutical medicines. This department comprises several complementary functions focused on the progression of a portfolio of biopharmaceuticals from initial antibody discovery, expression and characterisation to molecular engineering and biological and physiochemical profiling.

Within the Biopharm Discovery Unit, the Molecular Design and Engineering (MDE) group takes accountability for antibody engineering and developability profiling prior to candidate selection to continuously improve molecule quality and transform discovered leads into potential therapeutics.

We are currently seeking an experienced laboratory scientist with a deep understanding of antibody analytics to join the developability profiling group within MDE. The predominantly lab-based role will involve developing and performing high throughput analytical methods/screens (existing and/or new) to rapidly profile a large panel of biopharmaceuticals based on their biophysical and chemical stability properties. The candidate will be expected to act as a Subject Matter Expert (SME) in antibody analytics and characterisation in order to recommend selection of suitable candidates that produce the desired developability characteristics.

You will have the opportunity to both lead projects and build capability, for example in automated workflows, and will be expected to influence scientific direction within the group.

The successful candidate will have extensive experience in antibody characterisation, including biophysical analysis and PTM assessment. They will be abreast of the latest literature and developments in the field. Although predominantly lab-based, the role also involves important aspects of verbal and written communication and requires good organisation as well as a broader scientific knowledge. You will be expected to develop, train and mentor junior members of staff, and will have demonstrated problem solving skills. Both individual and team working are required and therefore the role will suit a scientist with good interpersonal skills, abilities in data analytics, independence and self-motivation.

Closing date for applications: Sunday 29th March

During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process.

If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.

When applying for this role, please use the ‘cover letter’ of the on-line application to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

Thank you for your interest in this opportunity.


Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

  • PhD or equivalent in analytics, biochemistry, biophysics or related discipline
  • Demonstrable extensive post-graduate experience in antibody analytics either in academic or industrial setting (e.g. in early discovery/CMC analytical)
  • Extensive experience of profiling biopharmaceuticals in a range of analytical methods, such as: mass spectrophotometry, light scattering, SEC-HPLC, RP-HPLC, fluorescence/UV spectroscopy etc.
  • Deep understanding of developability liabilities of biopharmaceutical molecules
  • Experience of leading projects or initiatives with the ability to plan, co-ordinate and deliver complex work packages

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

  • Experience of developing miniaturized/high throughput assays
  • Knowledge and/or practical lab experience in Protein purification/CMC
  • Knowledge of antibody sequence/structure-function relationship
  • Understanding of Antibody Discovery processes

Why GSK?

Our values and expectations are at the heart of everything we do and form an important part of our culture.

These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

  • Operating at pace and agile decision-making – using evidence and applying judgement to balance pace, rigour and risk.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Continuously looking for opportunities to learn, build skills and share learning.
  • Sustaining energy and well-being
  • Building strong relationships and collaboration, honest and open conversations.
  • Budgeting and cost-consciousness

As a company driven by our values of Patient focus, Transparency, Respect and Integrity, we know inclusion and diversity are essential for us to be able to succeed. We want all our colleagues to thrive at GSK bringing their unique experiences, ensuring they feel good and to keep growing their careers. As a candidate for a role, we want you to feel the same way.

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Please don’t hesitate to contact us if you’d like to discuss any adjustments to our process which might help you demonstrate your strengths and capabilities. You can either call us on 0808 234 4391, or send an email

As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.

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Please apply via recruiter’s website.