Principal Researcher, Immunohistochemistry (IHC) and Imaging

Eisai Inc.

Cambridge, MA, United States

Eisai Inc. was established in 1995 and began marketing its first product in the United States in 1997. Since then we have rapidly grown to become a fully integrated pharmaceutical business. Eisai’s areas of commercial focus include neurology, gastrointestinal disorders and oncology/critical care. The company serves as the U.S. pharmaceutical operation of Eisai Co., Ltd., a research-based human health care (hhc) company that discovers, develops and markets products throughout the world. 

Eisai has a global product creation organization that includes U.S.-based R&D facilities in Massachusetts, New Jersey, North Carolina and Pennsylvania as well as manufacturing facilities in Maryland and North Carolina. The company’s areas of R&D focus include neuroscience; oncology; vascular, inflammatory and immunological reaction; and antibody-based programs. 

Eisai recognizes that we are the Company’s greatest asset. To this, Eisai is committed to providing us an enabling and empowering work environment that allows us to grow and thrive. In our diverse organization, we adhere to a strict commitment to our values of Integrity, Respect, Professionalism, Quality and Teamwork. We therefore invite you to explore this job opportunity or any others that may match your qualifications and interests. 

Eisai Center for Genetics Guided Dementia Discovery (G2D2) seeks a new Principal Researcher, Immunohistochemistry (IHC) and Imaging team member to contribute to our discovery biology efforts by conducting a wide variety of immunohistochemical studies on tissues from animal models and humans.

The primary responsibilities of this role will be to develop and perform imaging based assays, including generating tissue sections, designing, validating, and performing manual and automated immunohistochemistry, immunofluorescence and in situ hybridization experiments, microscopy, and image analysis in support of the discovery of drugs for the treatment of Alzheimer’s disease and other dementias.

Job Responsibilities 

* Independently develop, optimize, and validate protocols for single and multiplexed immunohistochemistry, immunofluorescence and in-situ hybridization

* Prepare tissue and cut sections on a cryostat and microtome

* Image acquisition using microscopes (confocal, epifluorescence, brightfield) and slide scanners

* Perform software-based image analysis and quantification

* Generate accurate and detailed study reports and maintain other necessary records including a lab notebook

* MS or BS in biology or related field and 3+ years laboratory experience 

Industry experience preferred

* Experience with all aspects of tissue 

processing (fixation, embedding, sectioning), and staining techniques 

(immunofluorescence, immunohistochemistry, in situ hybridization, histological 

stains) is required 

* A working knowledge of mouse and human neuroanatomy is 

strongly preferred

* Experience with confocal, epifluorescence, and 

brightfield microscopy is required

* Expertise in utilizing image analysis 

software (e.g. Imaris, Halo, Matlab) is required

* Experience with laboratory 

rodents (mouse) is required

* Experience with digital slide scanners (e.g. 

Leica Versa) is preferred

* Experience with automated staining platforms 

(e.g. Leica BondRx and/or Ventana Discovery Ultra) is preferred

* Excellent 

written and verbal communication skills

* Highly motivated, able to work 

independently, creative, and a great-problem solver

* Demonstrated ability to 

work well in a team/ matrixed environment

About Eisai Center for Genetics Guided Dementia Discovery (G2D2)

Recognizing the potential for human genetics and precision chemistry to disrupt the drug discovery paradigm, Eisai recently announced establishment of the new Eisai Center for Genetics Guided Dementia Discovery (G2D2). This industry-unique center and occupies a purpose-designed state-of-the-art 50,000 sq. ft. research facility in Cambridge, MA.

The mission of the new center is to accelerate drug discovery and development using human genetics to drive multi-disciplinary team-based progress towards medicines that address unmet patient needs.

The predominant research focus of G2D2 will be immunodementia: a new concept for next-generation therapeutics for Alzheimer’s Disease and other dementias that targets immune/inflammation related mechanisms. Our approach is premised upon and continuously incorporates robust insights from human genetics and other sources of human biology. This research focus builds upon Eisai’s considerable experience in and commitment to neurology research, and to our human health care mission which recognizes the profound impact of Alzheimer’s and related dementia on patients and their caregivers. More information about G2D2 is provided here (, and about Eisai’s Neurology strategy and pipeline are provided here (  

You will join a highly interactive and collaborative team spanning a broad range of drug discovery capabilities including: data sciences (genetics and informatics), wet lab biology (in-vitro and in-vivo), drug discovery platforms (biochemistry, chemical biology, assay development, screening, drug safety and DMPK), and chemistry (including application of novel small molecule and anti-sense oligonucleotide approaches). At Eisai, we highly value both internal and external collaboration and pursue flexible research models with a range of external scientific partners to accelerate delivery of innovative medicines. As an Eisai employee you will also spend at least 1% of your working time with patients and families to ensure that the innovation you drive is based on an understanding of their real needs.


Here at Eisai, we are rewarded with highly competitive salaries, incentive awards, a comprehensive benefits package (Medical, Dental, Prescription and Vision Plans) 401k, Flexible Spending Accounts, Life and Disability Insurance, and other great programs. 

Eisai is committed to a policy of equal employment opportunity for all employees and applicants. The Company also strives for a work environment free from discrimination and harassment. It is Eisai’s policy to comply with all applicable federal, state and local laws and regulations regarding nondiscrimination in employment and not to discriminate against any employee or applicant for employment on the basis of any protected status, including, but not limited to, race, color, national origin, religion, sex, age, disability, pregnancy, ancestry, creed, alienage or citizenship status, sexual orientation, gender identity and expression, marital status, military/veteran status, genetic information, or any other protected characteristic as established by law. 

Eisai is an Equal Opportunity Employer &ndash; Minority / Female / Disability / Vet from tblHiringOrgDefaults<img height=1 width=1 border=0 src= />

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