Institute of Hepatology, Foundation for Liver Research

Principal Investigator/Group Leader

Institute of Heptology, London Foundation for Liver Research

London, United Kingdom

Institute of Heptology, London

Foundation for Liver Research

Post title: Principal Investigator/Group Leader in Gut Microbiome & Chronic Liver Disease

Employer: Foundation for Liver Research (RCN1134579)

Website: www.liver-research.org.uk

Location: Institute of Hepatology, Foundation for Liver Research, 111 Coldharbour Lane, 

London SE5 9NT

Salary: A competitive salary is offered depending on experience

Duration: 3-5 years in the first instance

Closing date for applications: The Foundation is seeking to recruit an exceptional candidate and the post will remain open until that individual has been recruited.

Increasing evidence points to a central role for gut microbial dysbiosis and increased bacterial translocation in the development and progression of chronic liver injury and disease. We are seeking an established senior scientist/microbiologist to lead an active research programme aimed at investigating the Gut-Liver axis in Alcoholic and Non-Alcoholic Liver disease.

Applicants are requested to submit research proposals aimed to delineate the pathways associated with gut or intestinal dysfunction in chronic liver disease and actively pursue specific and novel pre-clinical interventional strategies. We would be particularly interested in studies that include (1) the use of bacteriophages to modulate the gut microbiome (2) mechanisms to repair the ‘leaky’ gut or (3) microbial metabolic interactions during liver disease.

This position comes with a significant support package which includes a fully functional and equipped laboratory together with the funding for 2 support staff (1 post-doctoral fellow and 1 technician) and seed-consumable funding for an initial 3 years.

The appointee will be based at the Institute of Hepatology, London, a purpose-designed three storey new building which offers an exciting and innovative multi-disciplinary research environment with high-level specialist equipment and facilities. This role would suit a forward-thinking leader capable of linking with existing lines of research at the Institute led by immunologists, clinicians and basic scientists. Complimentary research streams at the Institute include understanding the inflammatory mediators associated with liver injury, identification of the functional properties of the microbiome in chronic liver disease and the development of ex-vivo models of the gut-liver axis. All individual projects within the Institute’s research portfolio have clinical translational objectives and interaction and cross-collaboration between the groups is strongly encouraged, with sharing of expertise, facilities and equipment.

The Institute of Hepatology is an independent research organisation directly managed and core funded by the Foundation for Liver Research. The Institute is affiliated to King’s College London and King’s College Hospital and the successful candidate will have an honorary contract with KCL and the opportunity in due course to apply for an Adjunct position.

For further details and a Job Description:

http://www.liver-research.org.uk/liver-foundation/jobopportunities/rs6jd.html

To apply: please submit a detailed curriculum vitae that includes research experience to date and a 2-page outline of possible future research. Send to: Natalie Day, Head of Administration

n.day@researchinliver.org.uk Tel: 020 7255 9832. Please quote Job Ref RS36

For informal discussions regarding the post contact Dr Shilpa Chokshi, Chief Scientific Officer

s.chokshi@researchinliver.org.uk

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Position

Principal Investigator/Group Leader