Cancer Research UK Manchester Institute, UoM

Principal Bioinformatician

Cancer Research UK Manchester Institute, UoM

Manchester, United Kingdom

Principal Bioinformatician

  • Salary within the range of £31,334 – £41,224 per annum (depending upon experience)
  • Job Ref: MI/19/72_2
  • Duration of post: Fixed term until 31st March 2022

About the role:
The overall goal of the Cancer Biomarker Centre (CBC) in the CRUK Manchester Institute led by Professor Caroline Dive CBE, is to develop, validate, and implement biomarkers that facilitate the optimisation of cancer patient treatment – personalised medicine. In this regard, CBC is an acknowledged world leader in the study of minimally invasive biomarkers (liquid biopsies) suitable for patient monitoring. Our biomarker research integrates clinical, molecular and computational science into a highly interdisciplinary programme; advanced computational biology is critical to the biomarker agenda.

An exciting opportunity now presents for a Principal Bioinformatician to join the CBC, positioned within the Bioinformatics and Biostatistics team (BBS). You will work alongside a multidisciplinary team of clinicians, biologists, chemists and computational scientists to analyse genomics data arising from patient blood samples. The primary focus will be to apply a wide range of analysis approaches (including Machine Learning and Bayesian modelling) to DNA and RNA sequencing data from Circulating Tumour Cells (CTCs) and circulating tumour DNA (ctDNA) in order to develop novel genomics-based biomarkers that help better characterise patient tumours.

Meet our bioinformaticians and statisticians within our service and research groups:

About you:
You should have a PhD in Computational Biology/Bioinformatics, Mathematics (or related discipline) or a relevant postgraduate degree in a related discipline and significant relevant experience. You will have significant experience in writing code for robust and reproducible analysis and demonstrable experience in many areas of bioinformatics pertaining to the analysis of high-throughput data. An understanding of liquid biopsies, cancer genomics, and cancer biology are desirable.

You will have excellent communication skills and the ability to converse successfully with interdisciplinary collaborators from non-mathematical backgrounds. Experience of multidisciplinary teamwork would be beneficial.

Why choose Cancer Research UK Manchester Institute?
The Cancer Research UK Manchester Institute (, an Institute of The University of Manchester (, is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK (, the largest independent cancer research organisation in the world. We are currently situated at the internationally-renowned life sciences campus at Alderley Park in Cheshire England, 15 miles from Manchester, a vibrant and dynamic city surrounded by beautiful countryside.

We are partnered with The Christie NHS Foundation Trust (adjacent to the CRUK MI Paterson Building) in South Manchester (, one of the largest cancer treatment centres in Europe. These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes.

Our aim is to understand the fundamental basis of cancer and apply that knowledge to developing new treatment strategies for cancer patients. Our advanced research programmes span a spectrum of cancer research, from the molecular and cellular basis of cancer through to drug discovery, translational research and clinical trials.

The Institute has access to outstanding laboratory facilities and exceptional core services, including next generation sequencing, microarrays, confocal microscopy, bioinformatics, histology and mass-spectrometry.

How to apply?
To apply for this position please visit our website:

For any informal enquiries about this post, please contact Dr Alastair Kerr via email:
Please note this vacancy will close for applications at 11:59pm on the closing date specified.
Additional Information:
On the 26th April 2017 The Paterson Building, which housed most of the Cancer Research UK (CRUK) Manchester Institute, caught fire resulting in significant damage. We shall be rebuilding our world-class research facilities and we would like to make you aware that in the meantime, the primary place of work for this position will be at the internationally-renowned life sciences campus at Alderley Park, which has excellent facilities to carry out research. We anticipate that this will be for a few years, after which we will return to our original site in Withington, Manchester, next to The Christie NHS Foundation Trust (Wilmslow Road, M20 4BX).

Please apply via recruiter’s website.