The main focus of the Division of Nephrology of the Department of Internal Medicine III (Head: Prof. Dr. med. Ch. Hugo) is the diagnosis and treatment of renal diseases and hypertension. The experimental laboratory of the Division of Nephrology has a lot of national and international research visibility in regard to renal regeneration after injury. Our laboratory identified a precursor cell niche within the juxtaglomerular apparatus being responsible for glomerular mesangial regeneration after mesangiolysis. We could also define that endothelial cell repair is solely dependent on intrinsic cells of the kidney and not on bone marrow derived or other extrinsic cells of the body. It is still a major debate in the research community, whether specific endothelial precursor cell niches exist or whether any endothelial cell can be involved in regeneration. Our group focuses on regenerative mechanisms in the kidney with respect to molecular and cellular interactions of resident and extrinsic cell types by generating and using transgenic mice, in vivo gene transfer methods, kidney organoids from human iPS cells as well as highly sophisticated intravital microscopy in mice.
The Experimental Lab of the Division of Nephrology has a vacant position for
Predoctoral Fellow / PhD student (f/m/x)
The position is immediately available. The contract is planned for 36 months. The successful candidate will work on a DFG-sponsored project on the identification and characterization of endothelial cell regeneration mechanisms in the kidney.
Microvascular injury is a common finding in many acute forms of renal injury such as thrombotic microangiopathy, acute renal failure, scleroderma renal crisis, vasculitis and also most types of glomerulonephritis. To study vascular injury and repair mechanisms an inducible model of selective endothelial injury was established (Nephrol Dial Transplant 2008 Apr;23(4):1144-56).
• Based on our previous work (J Am Soc Nephrol. 2016 Jun;27(6):1714-26) the PhD student will be expected to work on the characterization of different transgenic mouse strains to identify the source of renal endothelial regeneration.
• Within her / his work, IHC, FACS, cell sorting, single cell transcriptome and proteome analysis, as well as cell culture assays will be techniques (all of which are established within the group) being used in this thesis/project at the highest possible level.
• In addition, the longitudinal intravital microscopy of glomerular (and other renal) cells are planned for this Project.
• We are looking for highly motivated applicants pursuing a PhD thesis with translational potential in experimental nephrology / regenerative medicine.
• We offer an interesting research field with an excellent basic research scientific campus including the Center for Regenerative Therapies Dresden (CRTD), the Medical Faculty, the BIOTEC and the Max-Planck Institute for Cell Biology and Genetics in close neighbourhood to the historic city of Dresden.
• A Position according to the TV-L conditions (E13; 50 %)
A detailed CV (with publications, if available), cover letter and two references should be provided. Application of women is appreciated. Disabled persons with equal qualification will be preferred.
We kindly ask you to apply preferably via our online form to make the selection process faster and more effective. Of course, we also consider your written application without any disadvantages. We look forward to receiving your application, until April, 3th 2020 online with Registration number MK30920072. For further Information please contact Susanne Dollfus by telephone 0351-458-4233 or by e-mail: email@example.com