Preclinical Scientist – Immunology
MiroBio is a recently launched biologics company with a mission to treat a range of autoimmune and inflammatory disorders. The company is founded by leading immunologists at the University of Oxford who have spent over 15yrs focussed on understanding the mechanisms which underlie T-cell signalling. The technology is based on an IP portfolio of novel antibodies with the ability to activate inhibitory co-receptors on the surface of immune cells, with a deep mechanistic understanding, MiroBio is able to optimise these antibodies to create immune-modulatory therapies which have shown remarkable efficacy in preclinical models of disease. MiroBio is now building out the team and the platform, looking for strong antibody-development expertise to take the lead compounds to clinical proof-of-concept.
MiroBio is a well-funded spin-out from Oxford University. The company is based in Oxford, retaining close links to the world-class immunology expertise and clinical trial experience within the University.
Reporting to: Robert Boyd – Snr Director, Preclinical
Location: Initially at the BioEscalator – Oxford OX3
Long-term facilities will be accessible from central Oxford
We are looking for a highly motivated immunologist to help propel our novel therapeutic antibodies from discovery to the clinic. The immunologist will establish the cellular assays required to take our novel antibodies through the various stages of pre-clinical development. The immunologist will also help us analyse complex human disease models and input into our therapeutic strategies for autoimmune diseases. This role will enable the post holder to acquire a comprehensive overview of therapeutic antibody discovery and development. A focus on detail and quality are important for this role. Strong communication skills and adaptability are also requirements for this position.
• Development and application of cellular immune assays to progress antibody
• Development of flow cytometric and immunoassays for the characterization of
animal and patient samples. Development of immune cell assays using diseased
• Development of biomarker assays to support patient selection
• Working with external contractors and consultants to outsource key pre-clinical
studies. Technology transfer of assays to external contractors
• The preparation of preclinical documentation to support regulatory submissions
• Select, follow, and adapt experimental protocols and generate laboratory SOPs
• Contribute to wider project planning, including ideas for new research projects
• Contribute to discussions and share research findings with colleagues in partner
institutions and research groups
• Assist in the training and supervising/mentoring of junior researchers
Role qualification and requirements:
PhD in Immunology and cellular immunology background
3+ years in a biotech developing and conducting immunology cell-based assays to support therapeutic antibody or biologics programs
Experience in preparation of cell subsets from blood and their use in primary assays
Hands-on experience of multi-colour flow cytometry, ELISA and ELISPOT
Familiarity with Human immune disease models
Experience of working with external contractors and collaborators would be an advantage
Experience in the preparation of preclinical documentation to support regulatory submissions.