The Francis Crick Institute

Postdoctoral Training Fellow

The Francis Crick Institute

London, United Kingdom

Postdoctoral Training Fellow

This is a full-time, fixed-term (4 years) position on Crick terms and conditions of employment.

The research group

Understanding how a multiple cellular organism arises from a single cell is a major challenge in biology. Accurate and timely control of gene expression is an essential component of these complex developmental programs. The laboratory of Folkert van Werven aims to decipher principles of gene regulation in general, and specifically during cell differentiation. The research can be summarized with three questions: How do cells make a cell fate decision? How does transcription of noncoding RNAs and mRNA isoform regulates cell differentiation? How do mRNA modifications facilitate cell differentiation?

Project summary

Throughout mammalian, vertebrate and invertebrate development the starts of transcripts are highly regulated, leading to a high degree of transcript heterogeneity and production of many alternative transcript isoforms. However, the function and regulation of these alternative transcript isoforms is not well understood. Work in yeast has shown that upstream transcription events can lead influence and affect the expression of main transcript isoform. Work of my laboratory and other has shown that there are distinct mechanisms involving the transcription machinery and chromatin factors in place that control transcript isoform usage. The project goal is to establish a mammalian differentiation system and use various genomic techniques to the study the role of transcription of alternative mRNA isoforms in regulating gene expression. The successful candidate will work with members of the research group, but also with various science technology platforms.

Details of research projects currently being undertaken can be seen at: https://www.crick.ac.uk/research/labs/folkert-van-werven. Research techniques used in the laboratory include: single cell approaches, various genomic approaches, genetics, and molecular biology. Postdoctoral Training Fellows are expected to lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators). The ability to work in a team is essential.

Key experience and competencies

The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial. The ideal candidate must have:

  • Strong interest in basic research
  • Advanced experience with bioinformatics and genomics
  • Strong affinity with techniques in molecular biology and biochemistry
  • Interest in both bioinformatic analysis and bench work
  • Apart from working on the main project, a successful candidate should also be able to help others and collaborate with members of the research group

Essential

  • PhD in either Molecular biology/Biochemistry/Computational Biology/Bioinformatics or in the final stages of PhD submission
  • Good knowledge and experience in Bioinformatics/Computational biology/Molecular biology/Biochemistry
  • Technical expertise in various genomic techniques and data analysis
  • Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals
  • Evidence of data presentation at scientific meetings
  • Ability to work independently as well as interacting within a group

Desirable

  • Experience in mammalian cell culture
  • Experience in specific genomic techniques (such as TSS-seq, TT-seq, MNAse-seq, CLIP-seq)

Please apply via recruiter’s website.