The Francis Crick Institute

Postdoctoral Training Fellow– Schreiber Laboratory

The Francis Crick Institute


Job title: Postdoctoral Training Fellow

Location: The Francis Crick Institute, Midland Road, London
Contract: Full-time, Fixed-term (4 years)
Salary: Competitive with benefits, subject to skills and experience
Vacancy ID: 11566

Short summary

Schreiber lab at the Francis Crick Institute (London, UK) is looking for a postdoctoral researcher to study the molecular basis of autophagy – an intricate intracellular self-eating pathway essential for cellular homeostasis, quality control and self-defense. The Schreiber lab is an enthusiastic curiosity-driven lab with the mission to unravel the molecular basis of autophagy in order to aid the development of novel diagnostic and therapeutic tools to target the many human diseases associated with a deregulation of autophagy (e.g. cancer, infection and neurodegeneration). We are employing a highly interdisciplinary approach to understand the structural and mechanistic basis of the autophagy machinery, their complex posttranslational regulation and how the different functional units work together to form vesicular carriers (autophagosomes) tasked to deliver a range of cytoplasmic constituents to the vacuole/lysosome.

The lab is establishing a cell-free system to re-enact and visualize the process of autophagosome formation in the test tube allowing us to dissect the mechanism and its regulation at the molecular level. We are applying a combination of structural, biochemical, biophysical and cellular approaches to study the process at the highest possible spatial and temporal resolution. The lab is looking for a highly motivated postdoctoral researcher interested in using bottom-up approaches to understand the molecular basis and posttranslational regulation of autophagy. Applicants should have a strong background in biochemistry, structural biology or biophysics and an interest in autophagy.
Please direct any informal inquiries to:

About us

The Francis Crick Institute is a newly established world class biomedical discovery institute in the heart of London dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

• If you are interested in applying for this role, please apply via our website.
• The closing date for applications is 25 August 2019 at 23:30.
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

Please apply via recruiter’s website.