The Francis Crick Institute

Postdoctoral Training Fellow – Molodtsov Laboratory

The Francis Crick Institute

London, United Kingdom

Job title: Postdoctoral Training Fellow – Molodtsov Laboratory

Location: The Francis Crick Institute, Midland Road, London

Contract: Full time, Fixed term (4 years)

Salary: Competitive with benefits, subject to skills and experience

Vacancy ID: 011627

Short summary

Mechanobiology and biophysics group at the Francis Crick Institute is looking for a highly qualified biochemist to study microtubule cytoskeleton. Our goal is to unravel how force generation at microtubule tips leads to cell shape change and movement specifically during cell division. We use tools engineering, physics, chemistry and biology and aim to understand basic fundamental principles at the level of individual molecules. We have strong experience in single-molecule force spectroscopy using optical tweezers and single-molecule imaging. Previously we discovered molecular mechanisms used by growing and shrinking microtubule tips to generate forces (McIntosh et al., Q. Rev. Biophys., 2012, Molodtsov et al., Cell, 2016). 

We are looking for bold, imaginative, open, dynamic and collegial postdoctoral fellows. Good communication and organisational skills as well as PhD in a relevant area are required.

Candidates should have a solid background in protein biochemistry and molecular biology. They are expected to have a strong publication record and strong interest in quantitative biophysical methods and/or single-molecule methods. Experience with microscopy, biophysics and/or force spectroscopy is not required but welcome.

Project scope

The successful candidate will use in vitro assays to reconstitute biochemically multicomponent systems that drive force generation at microtubule tips. To investigate the underlying mechanisms, they will use TIRF microscopy and single-molecule imaging including single-molecule FRET and optical trapping as well as advanced data processing.

The project will benefit from close collaborations with leading experts in single-molecule imaging and force-spectroscopy both within the group and externally at the Francis Crick and Physics Department of the University College London with which we are affiliated. The candidate is expected to drive their own project and participate and contribute to interdisciplinary team that works on developing new tools for investigating reorganization of cytoskeleton and DNA by motor and non-motor complexes that generate and respond to mechanical forces.

For more information about the group and our research, please visit: https://www.crick.ac.uk/research/labs/maxim-molodtsov

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

  • If you are interested in applying for this role, please apply via our website.
  • The closing date for applications is 04 September 2019 at 23:45.
  • All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

Key words

  • Biochemistry
  • Microtubule
  • Tubulin
  • Cytoskeleton
  • TIPs
  • Biophysics
  • Reconstitution
  • Molecular motor
  • DNA segregation
  • Cell division
  • Single-molecule imaging
  • Single-molecule FRET
  • Optical tweezers
  • Force spectroscopy

Please apply via recruiter’s website.

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