Job title: Postdoctoral Training Fellow in Cellular Signalling and Cytoskeletal Function
Location: The Francis Crick Institute, Midland Road, London
Contract: Fixed-term, 4 years
Salary: Competitive with benefits, subject to skills and experience
Vacancy ID: 10788
We are looking for a motivated Postdoctoral Research Fellow to join the Cellular Signalling and Cytoskeletal Function laboratory headed by Michael Way at the Francis Crick Institute (https://michaelway0.wixsite.com/waylab). The position represents an exciting opportunity to work on a collaborative ERC synergy grant with Carolyn Moores (Birkbeck, London) and Edgar Gomes (IMM, Lisbon) to investigate the molecular, cellular and physiological diversity of the Arp2/3 complex. The project will involve close interactions and visits between all three groups to achieve our ambitious goal. The successful candidate will be expected to drive their own independent research programme to investigate the actin nucleating properties, dynamics and interactions of isoform-specific Arp2/3 complexes using biochemical and biophysical approaches including single molecule TIRF microscopy. Applicants should have a PhD with a biochemical background in actin, single molecule analysis and/or imaging.
The Arp2/3 complex consisting of seven protein subunits is essential to stimulate dynamic branched actin networks needed for multiple fundamental cellular processes during our development and throughout of life time (Campellone & Welch, 2010). The Arp2/3 complex has always been considered as a single entity, but in humans and other mammals, three of the complex subunits are encoded by two isoforms, thus allowing the formation of eight distinct Arp2/3 complexes. We previously demonstrated that Arp2/3 subunit composition dramatically affects the formation and stability of branched actin networks (Abella et al., 2016). Moreover, the Gomes lab demonstrated that specific Arp2/3 isoforms are essential for normal muscle development (Roman et al., 2017). The proposed project, which involves a close and interactive collaboration with the labs of Carolyn Moores (Birkbeck, London) and Edgar Gomes (IMM, Lisbon), will use biochemical and biophysical approaches to understand the regulation and properties of the eight different human Arp2/3 complexes during the assembly and disassembly of branched actin networks.
Campellone and Welch, 2010. A nucleator arms race: cellular control of actin assembly. Nature Rev Mol Cell Biol 11, 237-251.
Abella et al., 2016. Isoform diversity in the Arp2/3 complex determines actin filament dynamics. Nature Cell Biol
Roman et al., 2017. Myofibril contraction and crosslinking drive nuclear movement to the periphery of skeletal muscle. Nature Cell Biol 19, 1189-1201.
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
- If you are interested in applying for this role, please apply via our website
- The closing date for applications is 16 June 2019 at 23:30.
- All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.