Job title: Postdoctoral Training Fellow – Balchin Laboratory
Location: The Francis Crick Institute, Midland Road, London
Contract: Full time, Fixed term (4 years)
Salary: Competitive with benefits, subject to skills and experience
Vacancy ID: 012427
An exciting opportunity to be part of a pioneering biomedical research institute, dedicated to innovation and science. A postdoctoral research post in the laboratory of David Balchin is now available. We are looking for a highly motivated researcher to study how co-translational events influence nascent protein folding at the ribosome. The successful applicant will use a wide range of techniques to study complex protein biogenesis reactions in molecular detail, including hydrogen/deuterium exchange-mass spectrometry, cryo-EM and chemical crosslinking–MS. For more information about this research, please visit the external lab website: https://www.crick.ac.uk/research/labs/david-balchin. The successful applicant will have good communication and organisational skills and a PhD in a relevant area (or be in the final stages of completion).
The Balchin lab is interested in the cellular events that shape the earliest moments in the life a nascent protein. We reconstitute the intricate machinery of protein synthesis and folding using purified components, and use diverse biochemical, biophysical and structural approaches to determine how cellular factors modulate folding energy landscapes. By bridging the gap between in vitro and in vivo concepts of protein folding, we aim to understand the molecular principles underlying diseases of protein misfolding. The Balchin lab will be established at the Crick in January 2020.
Several projects are available, centred on studying the coordination between protein synthesis at the ribosome and folding of the nascent chain. Key outstanding questions include:
- What intermediates are formed during translation, and how do co-translational intermediates affect the efficiency of nascent protein folding?
- How does the rate of translation influence folding?
- How is the activity of molecular chaperones coordinated with protein synthesis?
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
- If you are interested in applying for this role, please apply via our website.
- The closing date for applications is: 10th November 2019 at 23:45.
- All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.