The Research Institute at Nationwide Children's Hospital

Post-Doctoral Scientists – Translational Neuroscience of Inherited Metabolic and Motor Neuron Diseases

Stephen Kaler, MD

Columbus, OH, United States

We are seeking Post-Doctoral Scientists (MD and/or PhD)- Multiple Postdoctoral Fellow Positions in Viral Gene Therapy, Motor Neuron Biology, and Mammalian Copper Transport: Columbus, OH, United States. | | The Kaler Laboratory, Center for Gene Therapy, is committed to dissecting the mechanisms and pathophysiology of inherited neurometabolic, motor neuron, and copper transport diseases and using the knowledge to improve health through rational remedies, including gene therapy. Patients and families affected by these conditions provide the impetus for scientific inquiry in the Laboratory.

 

In addition to molecular genetics, the Laboratory employs model organisms (yeast, mouse, zebrafish), cellular and biochemical approaches, and conducts clinical protocols. Adeno-associated virus (AAV)-mediated gene therapy for Menkes disease, choroid plexus–targeted gene therapy for Alpha-mannosidosis, studies of motor neuron degeneration mediated by p97/valosin-containing protein (p97/VCP), and inherited disorders of ATP7A-related copper transport represent current main directions. 

 

We are seeking highly motivated postdoctoral researchers who are clever, energetic, and have strong communication and interpersonal skills. Persons with broad experience in molecular and cellular biology, tissue culture, mouse husbandry and injection/dissection, or zebrafish modeling of disease are preferred. With guidance from Dr. Kaler, you will be responsible for leading an independent project that addresses the laboratory’s overarching aims and that aligns with your career goals. The job description includes, but is not restricted to performing research experiments, maintaining records of experiments, preparing laboratory reports, analyzing data and preparing publications and grant applications.

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Post-Doctoral Scientists – Translational Neuroscience of Inherited Metabolic and Motor Neuron Diseases