Team “Immunity in Health and Disease”, Institut Necker Enfants Malades (INEM), Paris, France
INEM is a biomedical research center aiming at fundamental discoveries with potential therapeutic implications. Our international faculty includes 19 teams and two departments: “Cell Biology (Growth and Signaling)” and “Immunology, Infectiology, and Haematology”.
INEM, together with the IMAGINE institute and the Hôpital Necker-Enfants Malades, make up the Necker campus which, supported by state-of-the-art core facilities, provides a vibrant environment for basic research and translational innovation. The Campus has a long-standing reputation for scientific excellence (8 principal investigators (PIs) at INEM received ERC awards) and key pioneering medical contributions (e.g. transplantation, biotherapy, gene therapy).
The team “Immmunity in Health and Disease” is investigating how B cells are involved in autoimmune and infectious diseases. We previously found that B cells could regulate immunity through the provision of IL-10 and IL-35 (Nature Immunology 2002, Immunity 2010, Nature 2014, Immunity 2018), and established that the major B cell subsets producing these cytokines in vivo were two distinct subsets of antibody-secreting cells (Immunity 2010, Nature 2014, Immunity 2018). We furthermore demonstrated that B cells contributed to the pathogenesis of autoimmune disease through the production of IL-6 (J Exp Med 2012).
The current project will investigate the molecular mechanisms controlling effector B cell differentiation and function, combining state-of-the-art proteomics, genetics, and microscopy approaches. These studies will be performed using experimental models and human cells. The goal is to identify novel molecular checkpoints controlling effector B cell differentiation and function to refine both our comprehension of B cell immunity and their therapeutic targeting.
The candidate should have a strong track record in molecular immunology or molecular biology.
The position is open. Salary will be according to experience following INSERM regulation.
Please send your application via email in English with CV, a brief outline of previous research, and contact details of three references to: firstname.lastname@example.org ; email@example.com
INEM- INSERM U1151 – Team – Immunity in Health and Disease
156-160, rue de Vaugirard
Selected publications from the team:
Lino AC. et al.Immunity. 2018. vol. 49 p120-133.
Kieback et al. Immunity. 2016. vol. 44 p1114-1126.
Shen et al. Nature Reviews Immunology. 2015. vol. 15 p441-451.
Shen P. et al. Nature. 2014. vol. 507 p366-370.
Neves P. et al. Immunity. 2010. vol. 33 p777-790.
Fillatreau S. et al. Nature Reviews Immunology. 2008. vol. 8 p391-397.
Fillatreau S. et al.Nature Immunology. 2002. vol. 3 p944-950