MRC Laboratory of Molecular Biology

Postdoctoral Scientist - Neurobiology

MRC Laboratory of Molecular Biology

Cambridge, United Kingdom

Postdoctoral Scientist
Starting Salary £30,914 – £33,755 per annum
Fixed term 3 years
MRC Laboratory of Molecular Biology, Cambridge, UK

An opportunity is available for a Postdoctoral Researcher in microscopy to join the group of Dr Albert Cardona at the MRC Laboratory of Molecular Biology (LMB) https://www2.mrc-lmb.cam.ac.uk/group-leaders/a-to-g/albert-cardona/ to implement state-of-the-art microscopy techniques for large-scale volume electron microscopy.

The Cardona Group’s research programme is to understand how the nervous system operates as an integrated whole. The lab has so far studied how the structure of a specific neural circuit relates to its function, both in health and in disease. Previous work has shown some aspects of how specific circuits work, such as circuits for learning and memory, for processing visual, olfactory, chemical, mechanical or noxius stimulus. But relating all circuits to each other requires understanding how output signals from independent circuit modules are integrated and used as inputs for further, downstream circuits, ultimately leading to circuits that implement the choice of a single, coherent behavioural response in exclusion to all possible others. To investigate how the outputs of one circuit are the inputs to another, while overcoming inter-individual variability, we must image at nanometre scale complete nervous systems.

Technological advances in electron microscopy have delivered two imaging modalities, FIBSEM and GridTape-TEM, that serve complementary purposes. With enhanced FIBSEM we can image with unprecedented resolution and reliability the complete nervous system of small, experimentally very valuable animals such as Drosophila larvae and adults. With GridTape-TEM, we can image much larger volumes at the cubic millimetre scale, such as the brains of small reptiles and amphibians that can teach us about how evolutionarily preserved structures also present in human brains communicate to each other.

We are looking for a motivated and skilled individual who will thrive in a highly collaborative and supportive research group. You should have a background on electron microscopy imaging and development, and be well acquainted with the setup, tuning, maintenance and operation of transmission and scanning electron microscopy instruments and associated instruments. You count among your skills hardware design and implementation for microscopy, and software engineering, and have a background in electron microscopy design or application.

The successful applicant will be awarded a three year Career Development Fellowship / Postdoctoral training Scheme position. This is a training and development position for a post-doctoral scientist who has recently completed their doctoral studies, is moving into a new research discipline or has limited experience of key transferable skills. The MRC LMB has excellent scientific core facilities and training opportunities.

Informal enquiries can be made to Dr Albert Cardona at acardona@mrc-lmb.cam.ac.uk. Additional information about the Neurobiology Division and the Laboratory as a whole can be found at http://www.mrc-lmb.cam.ac.uk.

The MRC Laboratory of Molecular Biology is a research institute within UK Research and Innovation (UKRI). UKRI is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at www.ukri.org.

Working for UKRI MRC provides a whole host of benefits including a defined benefit pension scheme, excellent holiday entitlement (40 ½ days including bank holidays and privilege days) and Benenden Healthcare membership. You will also have access to employee shopping/travel discounts, on site sport and social facilities, as well as salary sacrifice cycle to work schemes and childcare vouchers.

To apply and access full details of the vacancy please visit our job board at https://mrc.tal.net/vx/appcentre-int/candidate/post/2607/en-GB
If you are unable to apply online please contact us at recruit@mrc-lmb.cam.ac.uk.

Closing date: 7 January 2020

Final appointments will be subject to a pre-employment screening.

The Medical Research Council is an Equal Opportunities Employer who participates in the Disability Confident scheme.

Please apply via recruiter’s website.

Quote Reference: Reference: PR20952