MRC Laboratory of Molecular Biology

Postdoctoral Scientist

MRC Laboratory of Molecular Biology

Cambridge, United Kingdom

Postdoctoral Scientist/CDF
£30,914 – £33,755 per annum
3 years fixed term
MRC Laboratory of Molecular Biology, Cambridge, UK

We are looking for a postdoctoral scientist to join the group of Dr Sjors Scheres to work on the structural characterisation of amyloid filaments involved in neurodegenerative disease. Specifically, to undertake research to investigate the relationship between the structure of filamentous tau and alpha-synuclein and their ability to spread through the brain. Structure determination will be done using our in-house, state-of-the-art cryo-electron microscopy facility. Purification of filaments from human brain tissue, in vitro reconstitution of filaments, and biochemical characterisation will be done in close collaboration with the group of Dr Michel Goedert at MRC-LMB.

You are highly motivated, have a PhD in a biological subject, and you have an affinity for biophysical methods and numerical data analysis. Experience in the biophysical/biochemical characterisation of amyloid filaments or experience in experimental cryo-electron microscopy are important advantages.

Group web site:

The successful applicant will be awarded a three year Career Development Fellowship / Postdoctoral training Scheme position. This is a training and development position for a post-doctoral scientist who has recently completed their doctoral studies, is moving into a new research discipline or has limited experience of key transferable skills. The MRC LMB has excellent scientific core facilities and training opportunities.

The MRC Laboratory of Molecular Biology is a research institute within UK Research and Innovation (UKRI). UKRI is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at

Working for UKRI MRC provides a whole host of benefits including:
• Defined benefit pension scheme
• Excellent holiday entitlement (40 ½ days including bank holidays & privilege days)
• Benenden Healthcare membership
• Access to employee shopping/travel discounts
• On site sport and social facilities
• Salary sacrifice cycle to work scheme
• Childcare vouchers

To apply and access full details of the vacancy please visit our job board at
If you are unable to apply online please contact us at

Closing date: 19 October 2019

Final appointments will be subject to a pre-employment screening.
The Medical Research Council is an Equal Opportunities Employer who participates in the Disability Confident scheme.

Please apply via recruiter’s website.