The Heart Research Institute (HRI)

Postdoctoral Scientist (Molecular Biologist) - CVD

The Heart Research Institute (HRI)

Sydney, Australia

An exciting opportunity exists to join a successful research group as part of a partnership between The Heart Research Institute and the University of Sydney’s Charles Perkins Centre, a world class research and education precinct that is addressing the global epidemic of obesity, diabetes and cardiovascular disease – the leading causes of mortality in Australia.

THE HEART RESEARCH INSTITUTE is a centre of excellence in cardiovascular medical research affiliated with the Royal Prince Alfred Hospital and the University of Sydney located in Newtown, Sydney. Our research aims to understand the origins and mechanisms of cardiovascular diseases, including atherosclerosis and heart failure, and the contributions of diabetes and thrombosis.

THE CHARLES PERKINS CENTRE is facilitating world-class research; the translation of knowledge into practical solutions; the development of innovative, cross-disciplinary teaching programs to inspire the next generation of researchers; and forging new research partnerships within and beyond the University to enable the centre to deliver unique insights and results. This ambitious mission is underpinned by two key components:

•            An academic program that covers research and teaching

•            A state-of-the-art building with world-class facilities and equipment

The partnership between The Heart Research Institute and the Charles Perkins Centre brings together the best minds from across the academic spectrum through cross-disciplinary collaboration to develop innovative approaches to alleviating the burden of cardiovascular disease. For more information, visit The Heart Research Institute at and the Charles Perkins Centre at

The Heart Research Institute is seeking a post-doctoral Molecular Biologist to contribute to innovative and collaborative research programs with a focus on cardiovascular genetic approaches to better understand the biology of the vasculature. The position would be within the Atherosclerosis and Vascular Remodelling (AVRG) group, that uses genetic mouse models, lineage tracing, clonal analysis, single-cell RNA sequencing and primary cell culture to elucidate mechanisms. It is creating new murine models to mimic vascular disease in humans to be used to assess progression of CVD, and to assess therapeutic targets that promote regression.

The Molecular Biologist would also support other groups in HRI in collaborative projects that require particular expertise in genetic techniques.

Through their existing relationships with Institutions in the United Kingdom / New Zealand, the Molecular Biologist would assist the HRI with the recruitment of international scientists and students from international universities. They would also use these connections and work with the HRI to develop and build long-term relationships for the purpose of collaboration and recruitment.

They will use state-of-the-art genetic techniques including traditional Cre-Lox conditional/tissue-specific knockouts, lineage tracing, clonal analysis, fluorescence activated cell sorting (FACS) and next generation sequencing techniques such as RNA seq, single-cell RNA seq.

Essential criteria– you will have:

•            Due to funding arrangements and planned collaboration opportunities you will have Australian/New Zealand or UK citizenship

•            A PhD in a biological field

•            A knowledge of cell biology

•            Experience in Cre-LoxP systems and mouse genetics

•            A knowledge of genomics approaches and molecular biology

•            Some experience in FACS and cell sorting

•            Small animal handling an advantage

•            A knowledge of confocal microscopy techniques an advantage

•            A strong interest and commitment to translational research and producing high quality publications

•            High level of motivation and capacity for independent work

•            A track record of being team focused

•            Good interpersonal, written, and oral communication skills

Desirable criteria– you will have:

•            Experience in in vivo models of cardiovascular disease

•            Experience in models of immune/inflammatory disorders

•            Experience in animal surgery

•            Experience in in vitro cell culture and cell culture-based assays

Position requirements: In addition to the listed criteria, the successful candidate will be expected to contribute to the research program by performing a range of research-related tasks which may include the following:

•            Assist in the conduct and design of experiments

•            Assist in the general supervision of students in the laboratory

•            Assist in the preparation of documents (for grant applications, research/conference papers, ethics applications)

•            Provide administrative and financial management support for research projects and programs including the maintenance of electronic databases and records

•            Maintain particular lab equipment and materials, including waste disposal and ordering supplies

•            Maintain occupational health and safety standards

The position is full time; flexible working arrangements may be negotiated. The appointment period is initially for 3 years with the possibility of renewal. You will be employed by the Heart Research Institute but will work at our premises at the Charles Perkins Centre located nearby at the University of Sydney when required. This is an outstanding opportunity to develop skills and gain valuable experience conducting innovative research in state-of-the-art facilities.

Remuneration: A competitive remuneration package along with salary-packaging options.

How to apply: Your application should include:

•            a cover letter and detailed curriculum vitae (CV)

•            the names and full contact details of three professional referees (including email addresses)

Further information can be obtained by contacting Dr Ashish Misra by email at

Closing Date: Applications close: 31st July 2020

To apply for this position, you must have an appropriate Australian or New Zealand work rights or be a UK citizen.

Please note: Due to the volume of applications expected, only short-listed candidates may be contacted.

This is a Category A position according to the NSW Health Policy – Occupational Assessment, Screening Vaccination Against Specified Infectious Diseases. The successful applicant will be required to provide evidence of protection against the infectious diseases specified, at their own cost, prior to appointment.

The Heart Research Institute supports Equal Employment Opportunity. We value diversity and encourage applications from women, Aboriginal and Torres Strait Islanders, people with disability, LGBTQI individuals and applicants of diverse cultures and ages.

Apply with CV and Cover Letter

Must be a .doc, .docx, or .pdf file and no larger than 1MBMust be a .doc, .docx, or .pdf file and no larger than 1MB

Postdoctoral Scientist (Molecular Biologist) - CVD