Postdoctoral scientist in computer-aided drug discovery (f/m/d)

Helmholtz Zentrum München - German Research Center for Environmental Health (HMGU)

Neuherberg (bei München), Germany

Work group:

Institute of Structural Biology

Area of research:

Scientific / postdoctoral posts

Starting date:


Job description:

As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus, allergies and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle.

The Institutes of Structural Biology and Medicinal Chemistry at the Helmholtz Zentrum München have established a joint platform for structure- and fragment-based drug discovery, which integrates NMR methods, computational approaches, and chemical synthesis to develop and apply novel approaches beyond current state-of-the-art for the discovery of new targets and therapeutic small molecules. Therapeutic targets address a range of topics, ranging from diabetes, lung disease to targets in parasitic diseases and antibiotic resistance.

Postdoctoral scientist in computer-aided drug discovery (f/m/d)

Job Description

We seek candidates to further expand our portfolio of computational tools and methods for structure-based drug discovery. The position allows unique opportunity to merge innovative computing approaches with experimental feedback (Structural biology, NMR, fragments, medicinal chemistry). The scientist will be responsible for creating new virtual drug discovery pipelines. The scientist will develop new tools for turning structural information into novel therapeutic molecules. Ideally, we are looking for a candidate with experience in quantum chemistry, molecular recognition, building KNIME workflows, 3D docking and molecular dynamics of protein-ligand systems. Experience in programming, especially machine learning is desired.

 Your Qualifications

- Master’s degree and Doctoral degree in chemistry, biochemistry, physics, computer sciences or related
- Good object-oriented programming skills, documented experience in machine learning or AI interest would be highly appreciated
- Documented experience in quantum chemistry, molecular recognition or computational drug discovery techniques (docking, molecular dynamics, screening protocols, KNIME workflows)
- Commitment to work in the structure-based drug discovery field
- Strong motivation to contribute novel ideas to healthcare
- Creativity and a strong commitment to team work
- Strong communication and organizational skills are expected

 Our Offer

- Postdoctoral scientist position in the Institute of Structural Biology at the Helmholtz Zentrum München
- Innovative research focused on treatment of important human diseases
- Working in a vibrating and scientifically stimulating environment with excellent facilities for structural biology (crystallography, NMR, protein biochemistry, cell biology, imaging, animal models, and more)
- Excellent academic and industrial networking opportunities
- Support in developing management skills

At the Helmholtz Zentrum München, you can contribute together with leading researchers to the investigation of the development, prevention and treatment of environmental diseases such as diabetes, chronic lung diseases and allergies. In order to further promote your professional development, we offer extensive and targeted research training and career programmes. We support the reconciliation between work and private life with flexible working time models, occupational health management, day care facility for children, a childcare subsidy, Elder Care, as well as other counseling and support services.

Remuneration and benefits are in accordance with the collective agreement for the public service (TV EntgO Bund).

The position is (initially) limited to two years.

The activity involves special knowledge and experience specific to own scientific skills.

As a holder of the Total E-Quality Award, we promote equality of opportunity. In order to increase the proportion of women in management positions, we would be pleased to receive corresponding applications. Qualified applicants with physical disabilities will be given preference.

We are looking forward to receiving your comprehensive online application until April 1rd 2019.

Please apply via recruiter’s website.

Quote Reference: 2019/0129