Cedars-Sinai Medical Center (Cedars-Sinai)

Postdoctoral Scientist - Guarnerio/ Shiao Lab - Cancer Institute

Nancy Gonzalez

Los Angeles, CA, United States

Cedars-Sinai Medical Center ranks among the nation’s top ten non-university hospitals receiving federal funding for research and currently has more than 1,500 active research projects. Cedars-Sinai Cancer Center supports basic and clinical research in many cancer-related areas and researchers are seeking more effective ways to diagnose, treat and prevent many forms of cancer.


Cedars-Sinai is situated in the heart of Los Angeles at the border with Beverly Hills, in a very dynamic area of the city, and in the proximity of the University of California Los Angeles (UCLA). Ongoing education and training are offered throughout the institute, with the possibility to promotions to positions of instructor. Competitive salary and excellent benefits are also provided. 


Featured Postdoctoral Opportunities in Guarnerio Lab


Our lab’s goal is to understand the interactions between highly aggressive cancers and the non-malignant cells of the microenvironment in order to identify molecular vulnerabilities and develop novel therapies, especially in sarcoma and leukemia.

We work in a highly collaborative environment incorporating functional genomics, proteomics and biochemistry approaches that include single-cell and spatial single-cell transcriptomics, mass-cytometry, Hyperion imaging, and state of art mass spectrometry technologies.

We are seeking highly motivated and qualified individuals with a PhD in biochemistry, molecular or cell biology, cancer biology or cancer immunology to take over independent research projects in one of the following areas:


1-   Sarcoma Microenvironment

Soft-tissue sarcomas comprise a heterogeneous group of aggressive tumors that originate from cells belonging to the mesenchymal lineages. Compared to epithelial carcinomas, sarcomas have been less studied, and lack effective therapeutic alternatives to radiation and chemotherapy. With the aim of identifying new and more effective therapies for these tumors, the lab is employing syngeneic mouse models (Guarnerio et. al., Cancer Discovery 2015) to study immune and non-immune cells of the tumor microenvironment through single-cell transcriptomics and functional genomics.


2-   Leukemia Microenvironment

Our previous work showed that Mesenchymal Stem Cells (MSCs) are essential to maintain both normal hematopoietic stem cells and leukemic cells within the endosteal bone marrow niche (Guarnerio et. al., Stem Cell Reports, 2014; Guarnerio et. al., Nat Comm 2018). Future work will elucidate the cancer-sustaining interactions between leukemic cells and MSCs, and will employ spatial single-cell transcriptomic approaches as well as functional genomic screenings to define the molecules at the cross-talk between MSCs and leukemic cells.


3-   Cancer-associated circRNAs in the microenvironment

We have previously discovered tumor-associated circular RNAs (circRNAs) that act as oncogenes in the process of tumorigenesis (Guarnerio et. al. Cell 2016). More recently, we have observed that circRNAs can impact the tumor cells’ “secretome” and ultimately the composition of the tumor microenvironment (Guarnerio et. al., Cell Res 2019). Using novel biochemistry techniques refined in our lab, we are studying the unique mechanisms by which tumor-associated circRNAs define the immune and non-immune composition of the tumor mass.


For more information please visit:

https://www.cedars-sinai.edu/Research/Research-Labs/Guarnerio-Lab/


Our laboratory is situated in a highly collaborative and stimulatory environment. The work will be fully covered by grants from NIH-NCI, private foundations and a start-up package from the Cedars-Sinai Medical Center.


The ideal candidate will have:

·      PhD or MD/PhD degree

·      Technical proficiency in cell culture and hands on mouse work, experience in flow cytometry, experience in cancer biology and cancer immunology.

Individuals with training in cancer biology and functional genomics techniques (i.e. screening with CRISPR/Cas9 libraries) are particularly encouraged to apply.

Training in statistics or programming is a big plus but not required.

·      Publication track record (at least one peer reviewed paper as first author)

·      Excellent oral and written communication skills

·      Ability to perform and prioritize multiple simultaneous tasks.

·      Candidate should be industrious, highly collaborative, and enthused by a vibrant team environment.


Responsibilities:

·      Organize and manage experiments in a dynamic environment

·      Design, execute, and critically interpret experiments and present data in a cogent and compelling manner

·      Present data at lab meetings, institutional seminars and international conferences

·      Under the direction of the PIs, assist in drafting grant proposals, study protocols, and manuscripts


Interested applicants should email a letter describing their research interests and previous accomplishments, their CV, and names and contact information of three references to jlenia.guarnerio@cshs.org.

 

 

Featured Postdoctoral Opportunities Shiao/Knott Lab


This job posting is for a Department of Defense supported post-doctoral research position in the laboratories of Dr. Stephen Shiao and Simon Knott in the Department of Radiation Oncology and the Bioinformatics and Functional Genomics Institute in the department of Biomedical Sciences at Cedars-Sinai Medical Center in Los Angeles, CA. Our laboratories are part of a vibrant and growing research program in the immunobiology of cancer that has excellent opportunities for career development in the cancer biology, immunology, genomics and bioinformatics. This position is for a project studying the role of the immune system in regulating the response to cancer therapy (chemotherapy, radiation, targeted therapy and immunotherapy). We employ a variety of techniques including next generation sequencing particularly single-cell technique, the multiparametric flow cytometry and multiplex immunochemistry to study systemic and intratumoral immune responses in murine models of cancer and patient trial samples. 


For this postdoctoral research position, the candidate would be expected to work independently with a paired partner in bioinformatics (Knott Lab) on research projects designed in conjunction with two investigators: Dr. Stephen Shiao and Dr. Simon Knott. Candidates with experience in immunology, cancer biology, innate immunity, bioinformatics and/or radiation biology are preferred. Experience with molecular biology, cell culture and willingness to work with murine models is required. Familiarity with immunohistochemistry, flow cytometry, advanced sequencing techniques and the bioinformatics is helpful but not required. The postdoctoral scientist will assist in designing and conducting experiments, collection and analysis of data, preparation of data for publication and grant submission, presenting at both local and national meetings and applying for fellowships and grants. Teaching of other research staff, students, residents and fellows may be required.


Interested applicants should email a letter describing their research interests and previous accomplishments, their CV, and names and contact information of three references to stephen.shiao@cshs.org.




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Postdoctoral Scientist - Guarnerio/ Shiao Lab - Cancer Institute