University of Würzburg

Postdoctoral Scientist for Recombinant Protein Production of novel Split T cell engaging Antibodies (f/m/g)

University Hospital Würzburg

Würzburg, Germany

The Hemibody Lab at the University Hospital Würzburg / Germany (Department of Medicine II; Chair: Prof. Dr. Hermann Einsele)

is inviting applications for a

Postdoctoral Scientist for Recombinant Protein Production of novel Split T cell engaging Antibodies (f/m/g)

Our group is working on innovative antibodies, so called Hemibodies, which redirect immune cells for ground-breaking combinatorial immunotherapy of cancer.

Your challenge: To lead recombinant protein production of T-cell engaging Hemibodies. You will optimize upstream and downstream processing (USP and DSP) in eukaryotic cell systems. The candidate will be able to work on a high-impact project initially for a period of 1 year with a permanent contract possible afterwards. The project will focus on the pre-clinical development of Hemibodies against Multiple Myeloma.

Your profile: Applicants for this position must have solid experience in recombinant production of challenging proteins using CHO cells, high-density fermentation, batch and fed-batch processes. We further expect the successful candidate to improve the protein format by protein engineering in order to develop a platform technology that enables development of future GMP production. The applicant will have an extraordinary level of work ethic and enthusiasm, a team and result-oriented work style, excellent communication and organizational skills, the ability to face scientific challenges with creativity and dedication.

Your team: Our lab and department provides a stimulating and nurturing environment with a team of experienced, driven scientists. The Department of Medicine at the University Hospital Würzburg runs one of the largest hematology and bone marrow transplantation units in Germany, which provides numerous opportunities for bench-to-bedside interaction, education and clinical translation.

The candidate will be able to participate in the mentoring of PhD-/MD-students and contribute to lab management and organization. Disabled applicants will be preferentially considered in case of equivalent qualifications.

Application: Please send a letter of motivation (German or English), your CV and list of publications and potential referees to: Prof. Gernot Stuhler, stuhler_g@ukw.de.

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Position

Postdoctoral Scientist for Recombinant Protein Production of novel Split T cell engaging Antibodies (f/m/g)