MRC Laboratory of Molecular Biology

Postdoctoral Scientist / CDF

MRC Laboratory of Molecular Biology

Cambridge, United Kingdom

Postdoctoral Scientist / CDF
Starting Salary £30,914 to £33,755 per annum
Salary Band £30,914 to £39,381 per annum
MRC Laboratory of Molecular Biology, Cambridge, UK

The MRC Laboratory of Molecular Biology (LMB) is one of the birthplaces of modern molecular biology and has played an important role in the development of many new techniques, most notably protein crystallography, cryo-electron microscopy, DNA sequencing and monoclonal antibodies. The LMB has a clear goal of understanding biological processes at the molecular level. We aim to tackle difficult, long-term problems, which often require investment over many years. The LMB has also a long tradition in supporting computational method development for structural biology and aims to maintain this tradition.

We are looking for a highly motivated and skilled individual with strong background on development and use of computational tools for macromolecular crystallography and single particle cryoEM. You will work within the Computational Structural Biology group at the MRC LMB. Specifically, you will develop computational methods for modelling noisy and limited macromolecular crystallography data as well as tools for building / refinement / validation of atomic models using cryoEM maps. In addition, you will need to help LMB Structural Biologists to solve challenging practical structural biology problems.

Applicants will need to have experience of and ability to perform techniques relevant to the project. Particularly useful would be: experience on development and maintenance of large-scale software tools; very good understanding and experience in applied Bayesian statistics; knowledge of macromolecular crystallography at theoretical and practical level as well as relevant computational tools; model building and refinement using crystallography data as well as cryoEM maps. Experience in helping PhD students and young researchers would also be desirable.

Applicants should have a PhD in macromolecular crystallography, computational structural biology, computer science related fields or theoretical / computational physics. Applicants must also have: postdoctoral experience in computational and practical structural biology; must have been involved in software suit development; must have contributed to scientific papers.

You will report to Dr Murshudov and will interact and collaborate with other Postdoctoral Scientists, Research Support staff and Students, not only in your group, but also across the LMB and with external groups as necessary.

The successful applicant will be awarded a 3-year Career Development Fellowship / Postdoctoral training Scheme position. This is a training and development position for a post-doctoral scientist who has recently completed their doctoral studies, is moving into a new research discipline or has limited experience of key transferable skills. The MRC LMB has excellent scientific core facilities and training opportunities.

The MRC Laboratory of Molecular Biology is a research institute within UK Research and Innovation (UKRI). UKRI is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at

Working for UKRI MRC provides a whole host of benefits including a defined benefit pension scheme, excellent holiday entitlement (40 ½ days including bank holidays and privilege days) and Benenden Healthcare membership. You will also have access to employee shopping / travel discounts, on site sport and social facilities, as well as salary sacrifice cycle to work schemes and childcare vouchers.

To apply and access full details of the vacancy please visit our job board at
If you are unable to apply online please contact us at

Closing date: 5 April 2020

Final appointments will be subject to a pre-employment screening.
The Medical Research Council is an Equal Opportunities Employer who participates in the Disability Confident scheme.

Please apply via recruiter’s website.