About UCLA Department of Ophthalmology:
UCLA is an elite research university that is part of the prestigious University of California system. U.S. News & World Report has consistently ranked UCLA’s Department of Ophthalmology and Doheny Eye Institute among the top 5 in the nation for vision research and care. U.S. News & World Report also ranked UCLA 6th among the “Best Medical Schools for Research” in the US (2020) and 13th among all universities in the world (2018 Global Ranking). State-of-the-art facilities for proteomics, genomics, transgenic mice, retinal imaging and functional assessment, cellular mechanobiology, confocal imaging, and flow cytometry are all available for the project.
Postdoctoral Position in Vascular Inflammation at UCLA and Doheny Eye Institute: A postdoctoral position in vascular inflammation is available in the laboratory of Professor Kaustabh Ghosh at UCLA and Doheny Eye Institute. With funding from the NIH and a multidisciplinary approach, the Ghosh Research Group is committed to developing effective therapies for vision-threatening vascular defects in the eye.
This position will focus on the early inflammatory stages of diabetic retinopathy (DR) and age-related macular degeneration (AMD), potentially blinding eye diseases commonly associated with diabetes and aging, respectively. Currently, DR and AMD are clinically managed only in their advanced stages that are marked by excessive multiplication and leakiness of blood vessels in the inner and outer retina, respectively. However, there is growing recognition that more effective treatment of these conditions is possible by tackling them in the early stages when these blood vessels degenerate.
The Ghosh Lab is taking a multidisciplinary approach to understand and prevent this early loss of blood vessels in diabetes and aging. Integrating the principles of vascular biology, mechanobiology, inflammation, and bioengineering, our work has introduced a new paradigm that implicates vascular ‘stiffness’ as a crucial determinant of vascular degeneration associated with early DR and AMD. Our ongoing studies aim to identify the factors that alter vascular stiffness in the eye and uncover the mechanobiological mechanisms by which altered stiffness causes vascular loss in diabetes and aging. These studies, performed in collaboration with ophthalmologists and funded by the National Eye Institute/NIH, have the potential to identify new classes of drugs that restore normal vascular stiffness and function in the eye and thereby block DR and AMD progression in their early stages.
To drive this innovative research forward, we are looking for motivated individuals to perform multidisciplinary research involving animal and cell culture models of DR and AMD, and principles and techniques related to vascular biology, inflammation, and mechanobiology.
Requirements for the Position:
Candidates must be a recent (or soon-to-be) Ph.D. graduate or a current postdoctoral fellow in biomedical sciences/engineering, or related field. The successful applicant will have a strong research background in cell/molecular biology and biochemistry, and a record of first-authored publications. Previous experience with mammalian cell culture, fluorescence microscopy, flow cytometry, PCR, immunoblotting, and immunohistochemistry is desirable.
Candidates are required to submit application packets via the UC Recruit Website:
Interested applicants should additionally send (via email) a curriculum vitae (CV), statement of interests, and contact information for three references to:
Kaustabh Ghosh, Ph.D.
Department of Ophthalmology at UCLA
Doheny Eye Institute
The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy see: UC Nondiscrimination and Affirmative Action Policy.